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The Role of Brain Peptides in the Control of Anterior Pituitary Hormone Secretion

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Book cover Neuroendocrine Molecular Biology

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

A host of peptides act within the hypothalamus and also directly on the pituitary to control the secretion of anterior pituitary hormones. The classical releasing and inhibiting hormones act directly on the pituitary to inhibit or stimulate the release of anterior pituitary hormones. They appear also to act within the brain to modulate their own release and that of other releasing factors. With the discovery of many additional brain peptides, most of which were found initially in the gastrointestinal tract, many of these have also been examined and it is apparent that there are important hypothalamic actions of a number of these peptides to alter pituitary hormone secretion (1). In this paper, we will review some of our recent work in this area beginning with an examination of possible additional peptidic releasing or inhibiting factors which may directly alter pituitary hormone secretion, continuing with an examination of the intrahypothalamic action of the various peptides to alter their own release and that of pituitary hormones.

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References

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Author information

Authors and Affiliations

  1. Southwestern Medical School, University of Texas Health Science Center of Dallas, Dallas, Texas, 75235, USA

    S. M. McCann, W. K. Samson, M. C. Aguila, J. Bedran de Castro, N. Ono, M. D. Lumpkin & O. Khorram

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  1. S. M. McCann
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  2. W. K. Samson
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  3. M. C. Aguila
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  4. J. Bedran de Castro
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  5. N. Ono
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  6. M. D. Lumpkin
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  7. O. Khorram
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Editor information

Editors and Affiliations

  1. MRC Brain Metabolism Unit, Edinburgh, Scotland

    G. Fink  & A. J. Harmar  & 

  2. The International Foundation for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

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© 1986 Plenum Press, New York

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McCann, S.M. et al. (1986). The Role of Brain Peptides in the Control of Anterior Pituitary Hormone Secretion. In: Fink, G., Harmar, A.J., McKerns, K.W. (eds) Neuroendocrine Molecular Biology. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5131-3_10

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  • DOI: https://doi.org/10.1007/978-1-4684-5131-3_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5133-7

  • Online ISBN: 978-1-4684-5131-3

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