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Treatment Strategies for Memory Disorders

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Clinical Disorders of Memory

Part of the book series: Critical Issues in Psychiatry ((CIPS))

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Abstract

Establishment of etiology is an essential prerequisite for the treatment of memory disorders. It is estimated that 20% to 40% of the patients may have treatable disorders resulting from metabolic disturbances, alcohol abuse, intracranial pathology such as hematoma, tumor, and abcess, and psychiatric disorders such as dissociative disorders and depression. The remaining 50–60% of the cases of dementia are likely to suffer from primary degenerative diseases, including Alzheimer’s disease. This group of patients should be differentiated from the rapidly growing population of aged individuals in their 60s and 70s who suffer from progressive deterioration of cognitive and memory functions.

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References

  • Arrigo A, Braun P, Kauchtschischwili G, et al: Influence of treatment on symptomatology and correlated EEG changes in the aged. Curr Ther Res 1973; 15: 417–426.

    PubMed  CAS  Google Scholar 

  • Abuzzahah F, Merwin G, Zimmerman R, et al: A double-blind investigation of piracetam (nootropic) versus placebo in the memory of geriatric inpatients. Psychopharmacol Bull 1978; 14: 23–25.

    Google Scholar 

  • Bajada S: A trial of choline chloride and physostigmine in Alzheimer’s disease, in Corkin S, Davis K, Growden J (eds): A Report of Progress in Research, New York, Raven, 1982, pp 427–432.

    Google Scholar 

  • Branconnier RI: The efficacy of the central metabolic enhancers in the treatment of senile dementia. Psychopharmacol Bull 1983; 19: 212–219.

    PubMed  CAS  Google Scholar 

  • Caltagirone C, Albanese A, Gainotti G: Oral administration of chronic physostignvne does not improve cognitive or amnesic performances in Alzheimer’s presenile dementia. Int J Neurosci 1982; 16: 247–249.

    Article  PubMed  CAS  Google Scholar 

  • Caltagirone C, Albanese A, Gainotti G: Acute administration of individual optimal dose of physostigmine fails to improve amnesic performances in Alzheimer’s presenile dementia. Int J Neurosci 1983; 18: 143–147.

    Article  PubMed  CAS  Google Scholar 

  • Cermak LS: Comments on imagery as a therapeutic mnemonic, in Poon L, Fozard J, Cermak L (eds): New Directions in Memory and Aging: Proceedings of G Talland Memorial Conference Hillside, NJ: Lawrence Erlbaum, 1980, pp 507–510.

    Google Scholar 

  • Chase T, Durso R, Fedio P, et al: Vasopressin in treatment of cognitive deficits in Alzheimer’s disease, in Corkin S, Davis K, Growdon J (eds): Alzheimer’s Disease: A Report of Progress in Research. New York; Raven, 1982, pp 457–461.

    Google Scholar 

  • Chouinard G, Aimable L, Ross-Chouinard A, et al: Piracetam in elderly psychotic patients with mild diffuse cerebral impairment. Psychopharmacology 1983; 81: 100–106.

    Article  PubMed  CAS  Google Scholar 

  • Christie JE, Shering A, Ferguson J, et al.: Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. Br J Psych 1981; 138:46–50. Alzheimer’s disease, in New York, Raven, 1982, pp 413–419.

    Google Scholar 

  • Christie JE, Shering A, Ferguson J, et al: Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. Brit J Psychiatry 1981; 138: 46–50.

    Article  CAS  Google Scholar 

  • Cohen E, Wurtman R: Brain acetylcholine: Increase after systemic choline administration. Life Sci 1975; 16: 1095–1102.

    Article  PubMed  CAS  Google Scholar 

  • Craik FI: Age differences in human memory, in Birren J, Schaie K (eds): Handbook of the Psychology of the Aging. New York, Van Nostrand Reinhold, 1977, pp 384–420.

    Google Scholar 

  • Crook T, Ferris S, Sathananthan G, et al: The effect of methylphenidate on test performance in the cognitively impaird aged. Psychopharmacology 1977; 52: 251–255.

    Article  PubMed  CAS  Google Scholar 

  • Darvill FT: Double-blind evaluation of methylphenidate (Ritalin) hydrochloride—Its use in the management of institutionalized geriatric patients. JAMA 1959; 169: 1739.

    Article  Google Scholar 

  • Davis K, Mohs R, Tinklenberg J, et al: Physostigmine: Improvement of long-term memory processes in normal humans. Science 1978; 201: 272–274.

    Article  PubMed  CAS  Google Scholar 

  • Davis K, Mohs R, Tinklenberg J, et al: Cholinomimetics and memory: The effect of choline chloride. Arch Neural 1979a; 37: 49–52.

    Article  Google Scholar 

  • Davis K, Mohs R, Tinklenberg J: Enhancement of memory by physostigmine. N Engl J Med 1979b; 301: 946.

    PubMed  CAS  Google Scholar 

  • Denney NW: Clustering in middle and old age. Dev Psycho! 1974; 10: 471–475.

    Article  Google Scholar 

  • de Wied D: Behavioral actions of neurohypophysial peptides. Proc R Soc (London) Ser B Biol Sci 1980; 210: 183–195.

    Article  Google Scholar 

  • Domino E, Minor L, Duff I, et al: Effects of oral lecithin on blood choline levels and memory tests in geriatric volunteers, in Corkin S, Davis K, Growdon J (eds): Alzheimer’s Disease: A Report of Progress in Research. New York, Raven, 1982, pp 393–397.

    Google Scholar 

  • Eisdorfer C: A double-blind, comparative study of Hydergine sublingual tablets vs placebo in hospitalized geriatrics. Data on file at Sandoz Inc, USA, 1975.

    Google Scholar 

  • Eisdorfer C, Conner J, Wilkie F: The effects of magnesium pemoline on cognition and behavior. I Gerontol 1968; 23: 283–288.

    CAS  Google Scholar 

  • Eisdorfer C, Cohen D, Preston C: Behavioral and psychological therapies for the older patient with cognitive impairment, in Miller N, et al (eds): Clinical Aspects of Alzheimer’s Disease and Senile Dementia. New York, Raven, 1981, pp 209–224.

    Google Scholar 

  • Etienne P, Dastoor D, Gauthier S, et al: Lecithin in the treatment of Alzheimer’s disease. In Corkin S, Davis K, Growdon J (eds): Alzheimer’s Disease: A Report of Progress in Research. New York, Raven, 1982, pp 369–372.

    Google Scholar 

  • Ferris S: Empirical studies in senile dementia with central nervous system stimulants and metabolic enhancers, in Crook T, Gershon S (eds): Strategy for the Development of an Effective Treatment for Senile Dementia. New Canaan, Conn, Mark Powderly, 1981, pp 173–188.

    Google Scholar 

  • Ferris S, Reisberg S, Crook T, et al: Pharmacologic treatment of senile dementia: L-dopa, piracetam and choline plus piracetam, in Corkin S, et al (eds):Alzheimer’s Disease: A Report of Progress in Research. New York, Raven, 1982, pp 475–481.

    Google Scholar 

  • Gaitz C, Varner R, Overall J: Pharmacotherapy for organic brain syndrome in late life. Evaluation of an ergot derivative vs placebo. Arch Gen Psychiatry 1977; 34: 839–845.

    Article  PubMed  CAS  Google Scholar 

  • Gilbert J, Donnelly K, Zommer L, et al: Effects of magnesium pemoline and methylphenidate on memory improvement and mood in normal aging subjects. Aging Hum Dev 1973; 4: 35–51.

    Article  CAS  Google Scholar 

  • Giurgea CE: The nootropic concept and its prospective implications. Drug Dev Res 1982; 2: 463–474.

    Article  Google Scholar 

  • Glen A, Whalley L: Alzheimer Disease: Early Recognition of Potentially Reversible Deficits. Edinburgh, Churchill Livingston, 1979.

    Google Scholar 

  • Gurland B, Fleiss J, Goldberg K, et al: The geriatric mental state schedule, II. Factor analysis. Psychol Med 1976; 6: 451–459.

    Article  PubMed  CAS  Google Scholar 

  • Haubrick D, Wang P, Clody D, et al: Increase in rat brain acetylcholine induced by choline or deanol. Life Sci 1975; 17: 975–980.

    Article  Google Scholar 

  • Holliday A, Joffe J: A controlled evaluation of protriptyline compared to a placebo and to methylphenidate hydrochloride. J New Drugs 1965; 5: 257 (abstr).

    Google Scholar 

  • Hughes J, Williams J, Carrier R: An ergot alkaloid preparation (hydergine) in the treatment of dementia. Critical review of the clinical literature. J Am Geriatr Soc 1976; 24: 490–497.

    PubMed  CAS  Google Scholar 

  • Itil T, Menon G, Bozak M, et al.: The effects of oxiracetam (ISF 2522) in patients with organic brain syndrome (a double-blind controlled study with piracetam). Drug Dev Res 1982; 2:447–461.

    Google Scholar 

  • Kahn R: Psychological aspects of aging, in Rossmar I (ed): Clinical Geriatrics. Philadelphia, Lippincott, 1971.

    Google Scholar 

  • Kahn R, Zarit S, Hilbert N, et al: Memory complaint and impairment in the aged: The effects of depression and altered brain function. Arch Gen Psychiatry 1975; 32: 1569–1573.

    Article  PubMed  CAS  Google Scholar 

  • Kaplitz S: Withdrawn, apathetic geriatric patient responsive to methylphenidate. J Am Geriatr Soc 1975; 23: 71–76.

    Google Scholar 

  • Mindus P, Cronholm B, Levander S, et al: Piracetam-induced improvement of mental performance: a controlled study on normally aging individuals. Acta Psychiatr Scand 1976; 54: 150–160.

    Article  PubMed  CAS  Google Scholar 

  • Mohs R, Davis K: Choline chloride effects on memory: Correlation with the effects of physostigmine. Psychiatr Res 1980; 2: 149–156.

    Article  CAS  Google Scholar 

  • Mohs R, Davis K, Tinklenberg J, et al: Choline chloride effects on memory in the elderly. Neurobiol Aging 1980; 1: 21–25.

    Article  PubMed  CAS  Google Scholar 

  • Mohs R, Davis K, Johns C, et al: Oral physostigmine treatment of patients with Alzheimer’s disease. Am J Psychiatry 1985; 142: 28–33.

    PubMed  CAS  Google Scholar 

  • Peters B, Levin H: Chronic oral physostigmine and lecithin administration in memory disorders of aging, in Corkin S, Davis K, Growdon J (eds): Alzheimer’s Disease: A Report of Progress in Research. New York, Raven, 1982, pp 421–426.

    Google Scholar 

  • Plemor J, Willis S, Baltes P: Modifiability of fluid intelligence in aging: A short-term longitudinal training approach. J Gerontol 1978; 33: 224–231.

    Google Scholar 

  • Reisberg B, London E, Ferris S, et al: Novel pharmacologie approaches to the treatment of senile dementia of the Alzheimer type. Psychopharmacol Bull 1983; 19: 220–225.

    PubMed  CAS  Google Scholar 

  • Rigter H, Hannan T, Messing R, et al: Enkephalins interfere with acquisition of an active avoidance response. Life Sci 1980; 26: 337–345.

    Article  PubMed  CAS  Google Scholar 

  • Sanders R, Sanders J: Long-term durability and transfer of enhanced conceptual performance in the elderly. J Gerontol 1978; 33: 408–412.

    PubMed  CAS  Google Scholar 

  • Schmitt F, Murphy M, Sanders R: Training older adults. Free recall rehearsal strategies. J Gerontol 1981; 36: 329–337.

    PubMed  CAS  Google Scholar 

  • Sitaram N, Weingartner H, Gillin J: Human serial learning: Enhancement with arecoline and impairment with scopolamine correlated with performance on placebo. Science 1978; 201: 274–276.

    Article  PubMed  CAS  Google Scholar 

  • Sullivan E, Shedlack K, Corkin S, et al: Physostigmine and lecithin in Alzheimer’s disease, in Corkin S, Davis K, Growdon J (eds): Alzheimer’s Disease: A Report of Progress in Research. New York, Raven, 1982, pp 361–367.

    Google Scholar 

  • Tinklenberg J, Pigache R, Pfefferbaum A, et al: Vasopressin peptides and dementia, in Corkin S, Davis K, Growdon J (eds): Alzheimer’s Disease: A Report of Progress in Research. New York, Raven, 1982, pp 463–468.

    Google Scholar 

  • Venn RD: Review of clinical studies with ergots in gerontology. Adv Biochem Psychopharmacnl 1980; 23: 363–377.

    CAS  Google Scholar 

  • Vroulis G, Smith R: Cholinergic drugs and memory disorders in Alzheimer’s type dementia, in Enna SJ, Samorajski T, Beer B (eds): Brain Neurotransmitters and Receptors in Aging and Age-related Disorders. New York, Raven, 1981, pp 245–254.

    Google Scholar 

  • Winograd E, Simon E: Visual memory and imagery in the aged, in Poon L, et al (eds): New Directions in Memory and Aging: Proceedings of the George A Talland Memorial Conference. Hillsdale, NJ, Lawrence Erlbaum, 1980, pp 487–506.

    Google Scholar 

  • Yesavage JA: Imagery pretraining and memory training in the elderly. Gerontology 1983; 29: 271–275.

    Article  PubMed  CAS  Google Scholar 

  • Yesavage J, Tinklenberg J, Hollister L, et al.: Vasodilators in senile dementia: A review of the literature. Arch Gen Psychiatr 1979; 36:220–223.

    Google Scholar 

  • Yesavage J, Rose T, Spiegel D: Relaxation training and memory improvement in elderly normals. Correlation of anxiety ratings and recall improvement. Exp Aging Res 1982; 8: 195–198.

    Article  PubMed  CAS  Google Scholar 

  • Young M, Gibson W: How to Develop an Exceptional Memory. Hollywood, Calif, Wilshire, 1975.

    Google Scholar 

  • Zarit S, Kenneth D, Cole M, et al: Memory training strategies and subjective complaints of memory in the aged. Gerontologist 1981; 21: 158–164.

    Article  PubMed  CAS  Google Scholar 

  • Zepelin H, Wolfe C, Kleinplatz F: Evaluation of a year-long reality orientation program. J Gerontol 1977; 36: 70–77.

    Google Scholar 

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© 1986 Plenum Publishing Corporation

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Khan, A.U. (1986). Treatment Strategies for Memory Disorders. In: Clinical Disorders of Memory. Critical Issues in Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5128-3_13

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  • DOI: https://doi.org/10.1007/978-1-4684-5128-3_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5130-6

  • Online ISBN: 978-1-4684-5128-3

  • eBook Packages: Springer Book Archive

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