Abstract
Since the last meeting at Johns Hopkins in 1979, there has been a continued interest and a great deal of progress made in our understanding of the role of mitochondrial creatine kinase in muscle cells. The existence of the creatine phosphate shuttle as discussed by Bessman and Geiger (1) is now known to be an important aspect of muscle metabolism. There have been numerous studies on the effect of creatine kinase on respiration in heart muscle mitochondria. It is now well-documented that mitochondrial creatine kinase is responsible for stimulating respiration by utilizing ATP produced by oxidative phosphorylation and maintaining a constant high level of ADP available for continued phosphorylation. There has been much discussion about whether the ATP produced by oxidative phosphorylation is preferentially used by the mitochondrial creatine kinase. This aspect will be addressed by many of the other speakers here.
This work was supported by National Institutes of Health Grant HL17682.
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© 1986 Plenum Press, New York
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Hall, N., DeLuca, M. (1986). The Effect of Inorganic Phosphate on Mitochondrial, Creatine Kinase. In: Brautbar, N. (eds) Myocardial and Skeletal Muscle Bioenergetics. Advances in Experimental Medicine and Biology, vol 194. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5107-8_6
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DOI: https://doi.org/10.1007/978-1-4684-5107-8_6
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