Abstract
The unconditional requirement of closed membrane structures for oxidative energy conversion and conservation in eucaryotes entails the problem of subcellular compartmentation. Although much can be deduced from the in vitro characteristics of the permeability properties of the mitochondrial membranes and the behaviour of enzyme systems in vitro, understanding of the regulation of certain fundamental regulatory phenomena such as mitochondrial respiration has been awaiting data obtained in intact cells and tissues. Methodological progress in the field of metabolic compartmentation has brought into focus the subcellular distribution of effectors and the metabolites related to the tricarboxylic acid cycle.
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Kauppinen, R.A., Hiltunen, J.K., Hassinen, I.E. (1986). Mitochondrial Transmembrane Proton Electrochemical Potential, Di- and Tricarboxylate Distribution and the Poise of the Malate-Aspartate Cycle in the Intact Myocardium. In: Brautbar, N. (eds) Myocardial and Skeletal Muscle Bioenergetics. Advances in Experimental Medicine and Biology, vol 194. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5107-8_25
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DOI: https://doi.org/10.1007/978-1-4684-5107-8_25
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