Abstract
During the rest-work transition in skeletal muscle it has long been known that the increase in oxidative supply of ATP lags the increase in consumption of ATP. The balance is supplied by muscle stores of phosphocreatine (PCr) and glycolysis leading to accumulation of lactate in the muscle. Several hypotheses have been advanced to account for the lag in increase of \(\dot{V}{{O}_{2}}\). These have focused on limits to the delivery of substrates to the mitochondrion:
-
1)
limiting oxygen supply
-
2)
limiting supply of reducing equivalents
-
3)
limiting ADP and/or phosphate (Pi)
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Connett, R.J., T.E.J. Gayeski, and C.R. Honig. Lactate accumulation in fully, aerobic, working dog gracilis muscle. Am. J. Physiol. 246: H120 – H128, 1984.
Honig, C.R., T.E.J. Gayeski, and R.J. Connett. Balance between O2 availabiity and VO2 in rest-work transition as measured by myoglobin saturation in subcellular volumes. Adv. Exp. Med. Biol. In Press, 1984.
Honig, C.R., T.E.J. Gayeski, and R.J. Connett. O2 transport in the rest-work transition illustrates new functions for myoglobin. Am. J. Physiol. submitted.
Honig, C.R., C.L. Odoroff and J.L. Frierson. Capillary recruitment in exercise: rate, extent, uniformity, and relation to blood flow. Am. J. Physiol. 238: H31–42, 1980.
Honig, C.R. Hypoxia in skeletal muscle at rest and during the transition to steady work. Microvasc. Res. 13: 377–398, 1972.
Piiper, J., D.E. DiPrampero and P. Cerretelli. Oxygen debt and high energy phosphates in gastrocnemius muscle of the dog. Am. J. Physiol. 215: 523–531, 1968.
Veech, R.L., J.W. Randolph Lawson, N.W. Cornell, and H.A. Krebs. Cytosolic phosphorylation potential. J. Biol. Chem. 254: 6538–6547, 1979.
Kushmerick, M.J. Insight into the energetics of skeletal and smooth muscle by 31-P NMR. 2nd International Congress on Myocardial and Cellular Bioenergetics and Compartmentation, 1984.
McGilvery, R.W. and Murray, T.W. Calculated equilibria of phosphocreatine and adenosine phosphates during utilization of high energy phosphate by muscle. J. Biol. Chem. 240: 5845–5850, 1974.
Lawson, J.W.R. and R.L. Veech. Effects of pH and free Mg2+ on the keg of the creatine kinase reaction and other phosphate hydrolyses and phosphate tranfer reations. J. Biol. Chem. 254: 6538–6547, 1979.
Davis, E.J. and L. Lumeng. Relationships between the phosphorylation potentials generated by liver mitochondria and respiratory state under conditions of adenosine diphosphate control. J. Biol. Chem. 250: 2275–2282, 1975.
Jacobus, W.E., R.W. Moreadith and K.M. Vandegaer. Mitochondria respiratory control. J. Biol. Chem. 257: 2397–2402, 1982.
Connett, R.J., T.E.J. Gayeski and C.R. Honig. Lactate production in a pure red muscle in absence of anoxia: mechanisms and significance. Adv. Exp. Med. Biol. 159: 327–335, 1984.
Wilson, D.F., M. Stubbs, N. Oshino and M. Erecinska. Thermodynamic relationships between the mitochondrial oxidation-reduction reactions and cellular ATP levels in a cites tumor cells and perfused rat liver. Biochemistry 13: 5305–5311, 1974.
Rothschild, K.J., S.A. Ellias, A. Essig and H. E. Stanley. Nonequilibrium linear behaviour of biological systems. Biophys. J. 30: 209–230, 1980.
Gayeski, T.E.J. A Cryogenic Microspectrophotometric Method for Measuring Myoglobin Saturation in Subcellular Volumes; Application to Resting Dog Gracilis Muscle (Ph.D. dissertation). Rochester, NY: Univ. of Rochester, 1981. (Univ. Microfilms, No. DA8224720, Ann Arbor, MI, 1981 ).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Connett, R.J. (1986). Why is There a Delay in the Increased Oxygen Consumption during the Rest-Work Transition in Skeletal Muscle?. In: Brautbar, N. (eds) Myocardial and Skeletal Muscle Bioenergetics. Advances in Experimental Medicine and Biology, vol 194. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5107-8_20
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5107-8_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5109-2
Online ISBN: 978-1-4684-5107-8
eBook Packages: Springer Book Archive