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Glucocorticoid Receptors and Glucocorticoid Resistance in Human Leukemia in Vivo and in Vitro

  • Chapter
Steroid Hormone Resistance

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 196))

Abstract

Clinical measurements quantitating glucocorticoid receptor sites in leukemic blasts may give useful prognostic information. In childhood ALL, where the most data is available, “high” receptor content in peripheral or marrow blasts correlated with likelihood of remission on therapy, longer durations of remission and better prognosis generally. In lymphomas and CLL as well, high receptor content correlated with likelihood of response to steroid therapy, though the number of studies is less. In AML the correlation with receptor site content is moot, and in other leukemias the reports are less complete.

A model system for childhood ALL is provided by CEM cells, a glucocorticoid sensitive human cell line from a patient with the disease. These cells have glucocorticoid receptors which must be filled by hormone for >24 hr for cell lysis to begin. Four types of glucocorticoid resistance have been identified thus far in clones of these cells. Their distinctive properties are described and their relevance to clinical situations briefly discussed.

Work supported in part by a grant from the National Cancer Institute (CA 32226)

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Authors and Affiliations

  1. Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas, 77550, USA

    E. Brad Thompson

  2. Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, Maryland, 20814, USA

    Jeffrey M. Harmon

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  1. E. Brad Thompson
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  2. Jeffrey M. Harmon
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Editors and Affiliations

  1. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

    George P. Chrousos , D. Lynn Loriaux  & Mortimer B. Lipsett ,  & 

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© 1986 Plenum Press, New York

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Thompson, E.B., Harmon, J.M. (1986). Glucocorticoid Receptors and Glucocorticoid Resistance in Human Leukemia in Vivo and in Vitro . In: Chrousos, G.P., Loriaux, D.L., Lipsett, M.B. (eds) Steroid Hormone Resistance. Advances in Experimental Medicine and Biology, vol 196. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5101-6_8

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  • DOI: https://doi.org/10.1007/978-1-4684-5101-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5103-0

  • Online ISBN: 978-1-4684-5101-6

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