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The Common Marmoset as an Animal Model for Vitamin D-Dependent Rickets, Type II

  • Chapter
Steroid Hormone Resistance

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 196))

Abstract

Vitamin D3 is metabolized first in the liver to 25-hydroxyvitamin D3 [25(OH)D3] and then in the kidney mainly to lα, 25-dihydroxyvitamin D3 [1α, 25(OH)2D3] and 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3].1 The 1, α25(OH)2D3 is now regarded as the hormonal form of the vitamin in promoting intestinal calcium transport and bone mineral mobilization.1 The renal lα-hydroxylation of 25(OH)D3 is the rate-limiting step in the production of lα, 25(OH)2D3 and it is strictly regulated by the plasma levels of phosphorus, parathyroid hormone (PTH), calcitonin, estrogen, lα, 25(OH)2D3, and other steroid and peptide hormones.2 Since the discovery of lα, 25(OH)2D3, many lines of evidence have indicated that the hormone is incorporated by receptor mediation into the nuclear fraction of target cells before exerting its biological functions.3 This suggests that the lα, 25(OH)2D3 acts in a way similar to that of other steroid hormones.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142, Japan

    Tatsuo Suda, Naoyuki Takahashi & Toshimasa Shinki

  2. Department of Oral Pathology, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142, Japan

    Akira Yamaguchi

  3. Central Institute for Experimental Animals, 1430 Nogawa, Miyamae-leu, Kawasaki, Kanagawa, 211, Japan

    Yoshikuni Tanioka

Authors
  1. Tatsuo Suda
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  2. Naoyuki Takahashi
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  3. Toshimasa Shinki
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  4. Akira Yamaguchi
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  5. Yoshikuni Tanioka
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Editor information

Editors and Affiliations

  1. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

    George P. Chrousos , D. Lynn Loriaux  & Mortimer B. Lipsett ,  & 

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© 1986 Plenum Press, New York

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Suda, T., Takahashi, N., Shinki, T., Yamaguchi, A., Tanioka, Y. (1986). The Common Marmoset as an Animal Model for Vitamin D-Dependent Rickets, Type II. In: Chrousos, G.P., Loriaux, D.L., Lipsett, M.B. (eds) Steroid Hormone Resistance. Advances in Experimental Medicine and Biology, vol 196. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5101-6_28

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  • DOI: https://doi.org/10.1007/978-1-4684-5101-6_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5103-0

  • Online ISBN: 978-1-4684-5101-6

  • eBook Packages: Springer Book Archive

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