Altered Estrogen Action in the Senescent Rat Uterus: A Model for Steroid Resistance during Aging

  • George S. Roth
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 196)


The estrogen stimulated rat uterus serves as a useful model to examine steroid resistance during aging. This system exhibits receptor loss, impaired stimulation of RNA polymerase II and defects in nuclear translocation (or enhanced association) of receptor-estradiol complexes. All of these defects appear to contribute in part to decreased estrogen responsiveness of the senescent rodent uterus.


Estrogenic Stimulation Mature Nucleus Cytoplasmic Receptor Receptor Loss Biosynthetic Rate 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • George S. Roth
    • 1
  1. 1.Molecular Physiology and Genetics Section Gerontology Research Center, NIA, NIHBaltimore City HospitalsBaltimoreUSA

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