Androgen Receptors in Normal and Abnormal Male Sexual Differentiation

  • Terry R. Brown
  • Claude J. Migeon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 196)


Androgens act in target tissues via specific intracellular receptors. Indeed, all the functions controlled by androgen effects are mediated by androgen receptors, including sexual differentiation during fetal life, maturation at puberty and maintenance of sexual function and fertility in adult life. In this review, we will describe: A) the physiology of male sexual differentiation; B) abnormalities of male sexual differentiation; and C) studies of androgen receptors in man and their relationship to the pathophysiology of abnormal androgen action.


Androgen Receptor Leydig Cell External Genitalia Human Skin Fibroblast Gonadal Dysgenesis 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Terry R. Brown
    • 1
  • Claude J. Migeon
    • 1
  1. 1.Department of Pediatrics, Pediatric Endocrine Clinic and LaboratoriesThe Johns Hopkins University, School of MedicineBaltimoreUSA

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