Animal Models of Mineralocorticoid Resistance

  • Walter J. MeyerIII
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 196)


The development of animal models with a mineralocorticoid hormone resistance was a by-product of the development of animal models to study hypertension. One of the first models of sodium induced hypertension was developed by Rodbard with salt loading of chicken.1 In the early 1950’s Sapirstein2 and Toussaint3 followed with rat models for the development of salt induced hypertension. In 1953, Meneely and co-workers reported a linear relationship between mean blood pressure and salt ingestion in rats maintained on a specific sodium diet for long periods of time.4 Hypertension developed and persisted in all animals on high salt intake.4,5


Mineralocorticoid Receptor Salt Intake Aortic Cell Deoxycorticosterone Acetate Receptor Binding Characteristic 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Walter J. MeyerIII
    • 1
  1. 1.Department of PediatricsThe University of Texas Medical BranchGalvestonUSA

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