Abstract
In 1972, in a collaborative study between the Edelman and Tomkins laboratories, aldosterone was shown to bind two classes of sites in rat kidney preparations.1 Those with higher affinity were proposed as physiological mineralocorticoid Type I receptors, and those with lower affinity for aldosterone Type II, glucocorticoid receptors. The Type I aldosterone binding sites were subsequently shown to have very high affinity for 9α-fluorocortisol and deoxycorticosterone, as well as for aldosterone; moderate affinity for the physiological glucocorticoids cortisol and corticosterone; and relatively low affinity for the synthetic glucocorticoids dexamethasone and triamcinolone acetonide.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
G. Rousseau, J. D. Baxter, J. W. Funder, G. M. Tomkins, I. S. Edelman, Glucocorticoid and mineralocorticoid receptors for aldosterone. J. Steroid Biochem. 3: 219 (1972).
J. W. Funder, D. Feldman, I. S. Edelman, The roles of plasma binding and receptor specificity in the mineralocorticoid action of aldosterone. Endocrinology 92: 994 (1973).
D. Marver, J. Stewart, J. W. Funder, D. Feldman, I. S. Edelman, Renal aldosterone receptors: studies with [3H] aldosterone and the anti-mineralocorticoid [3H] spirolactone (SC-26304). Proc. Natl. Acad. Sci. USA 71: 1431 (1974).
J. W. Funder, D. Feldman, I. S. Edelman, Specific aldosterone binding in rat kidney and parotid. J. Steroid Biochem. 3: 209 (1972).
L. A. Pressley, J. W. Funder, Glucocorticoid and mineralocorticoid receptors in gut mucosa. Endocrinology 97: 588 (1975).
J. W. Funder, D. Duval, P. Meyer, Cardiac glucocorticoid receptors: the binding of tritiated dexamethasone in rat and dog heart. Endocrinology 93: 1300 (1973).
D. Duval, J. W. Funder, The binding of tritiated aldosterone in the rat liver cytosol. Endocrinology 94: 575 (1974).
M. N. Lassman, P. J. Mulrow, Deficiency of deoxycorticosteronebinding protein in the hypothalamus of rats resistant to deoxycorticosterone-induced hypertension. Endocrinology 94: 1541 (1974).
W. J. Meyer, N. R. Nichols, Mineralocorticoid binding in cultured smooth muscle cells and fibroblasts from rat aorta. J. Steroid Biochem. 14: 1157 (1981).
N. C. Lan, D. T. Matulich, J. A. Morris, J. D. Baxter, Mineralocorticoid receptor-like aldosterone-binding protein in cell culture. Endocrinology 109: 1963 (1981).
M. Moguilewsky, J. P. Raynaud, Evidence for a specific mineralocorticoid receptor in rat pituitary and brain. J. Steroid Biochem. 12: 309 (1980).
Z. Krozowski, J. W. Funder, Mineralocorticoid receptors in rat anterior pituitary: towards a redefinition of ‘mineralocorticoid’ hormone. Endocrinology 109: 1221 (1981).
Z. S. Krozowski, J. W. Funder, Mineralocorticoid receptors in lung. Endocrinology 109: 1811 (1981).
S. J. Quirk, J. E. Gannell, J. W. Funder, Aldosterone-binding sites in the pregnant and lactating rat mammary gland. Endocrinology 113: 1812 (1983).
B. S. McEwen, R. DeKloet, G. Wallach, Interactions in vivo and in vitro of corticoids and progesterone with cell nuclei brain regions and pituitary. Brain Res. 105: 129 (1976).
E. J. Nestler, T. C. Rainbow, B. S. McEwen, P. Greengard, Corticosterone increases the amount of protein I, neurone specific phosphoprotein, in rat hippocampus. Science 212: 1162 (1981).
Z. S. Krozowski, J. W. Funder, Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical steroid specificity. Proc. Natl. Acad. Sci. USA 80: 6056 (1983).
G. Stephenson, Z. S. Krozowski, J. W. Funder, Extravascular CBG-like sites in rat kidney and mineralocorticoid receptor specificity. Amer. J. Physiol. 15: F227 (1984).
G. Stephenson, M. Hammet, G. Hadaway, J. W. Funder, Ontogeny of renal mineralocorticoid receptors and urinary electrolyte responses in the rat. Amer. J. Physiol. 247: F665 (1984).
Z. S. Krozowski, G. Stephenson, S. Quirk, J. W. Funder, Mineralocorticoid receptors and extrinsic specificity-conferring mechanisms. In: Kaufmann W, Wambach G, Helber A, Meurer KA (eds) Mineralocorticoids and Hypertension. Springer-Verlag, Cologne, p. 3 (1983).
J. W. Funder, Z. S. Krozowski, Receptor heterogeneity. In: Receptor Update, Excerpta Medical Asia Ltd, p. 1 (1982).
J. W. Funder, Glucocorticoid receptors and the physiological roles of glucocorticoid hormones. In: Excerpta Medica International Congress Series, Elsevier Science Publishers BV (in press), 1984.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Funder, J.W. (1986). Aldosterone Receptors. In: Chrousos, G.P., Loriaux, D.L., Lipsett, M.B. (eds) Steroid Hormone Resistance. Advances in Experimental Medicine and Biology, vol 196. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5101-6_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5101-6_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5103-0
Online ISBN: 978-1-4684-5101-6
eBook Packages: Springer Book Archive