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In 1972, in a collaborative study between the Edelman and Tomkins laboratories, aldosterone was shown to bind two classes of sites in rat kidney preparations.1 Those with higher affinity were proposed as physiological mineralocorticoid Type I receptors, and those with lower affinity for aldosterone Type II, glucocorticoid receptors. The Type I aldosterone binding sites were subsequently shown to have very high affinity for 9α-fluorocortisol and deoxycorticosterone, as well as for aldosterone; moderate affinity for the physiological glucocorticoids cortisol and corticosterone; and relatively low affinity for the synthetic glucocorticoids dexamethasone and triamcinolone acetonide.
KeywordsMammary Gland Glucocorticoid Receptor Mineralocorticoid Receptor Triamcinolone Acetonide Aldosterone Receptor
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