Abstract
Dimethyl sulfoxide (DMSO) increases the permeability of tissue and has been reported to aid in the transport of drugs through intact skin. 1, 2 These experiments were designed to see if the drug would transport oxygen in the form of hydrogen peroxide (H202) through skin. A mass spectrometer was used to measure tissue gas levels (P02, PC02, PN2).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kligman, A.M. Topical pharmacology and toxicology of DMSO, JAMA 193:140 1965.
Leake, C.D. Biological actions of dimethyl sulfoxide. Ann. N.Y. Acad. Sci. 141:1–671 1967.
Wilson, W.R., Toomey, J.M., and Owens, G. Continuous measurement of local PO2 and PC O2 during the creation of bipedicle skin flaps in dogs. Surg. Forum 22:495 1972.
Hunt, T. K., Linsey, M., Sonne, M., and Jawetz, E. Oxygen tension and wound infection. Surg. Forum 22:47 1972.
Bethman, W. and Schottke, C. Action of local oxygen application on healing of pedicle flaps. Zbl. Chir. 92:ll1235 1967.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Plenum Press, New York
About this chapter
Cite this chapter
Myers, B., Donovan, W. (1973). Augmentation of Tissue Oxygen by Dimethyl Sulfoxide and Hydrogen Peroxide. In: Bruley, D.F., Bicher, H.I. (eds) Oxygen Transport to Tissue. Advances in Experimental Medicine and Biology, vol 37B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5089-7_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5089-7_10
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-5091-0
Online ISBN: 978-1-4684-5089-7
eBook Packages: Springer Book Archive