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Chemical Pharmacology of Ca2+ Channel Ligands

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New Insights into Cell and Membrane Transport Processes

Part of the book series: New Horizons in Therapeutics ((NHTH))

Abstract

A variety of terms, including Ca2+ antagonist, Ca2+ channel blocker, and slow channel blocker, have been applied to a structurally heterogeneous group of agents including the clinically available verapamil, nifedipine, and diltiazem (Fig. 1; for general reviews see Fleckenstein, 1977, 1983). With the recent introduction of 1,4-dihydropyridine analogues of nifedipine that function as calcium channel activators (Fig. 2, Bay K 8644 and CGP 28 392; Schramm et al, 1983), a more appropriate generic title might be calcium channel ligands.

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Authors and Affiliations

  1. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York at Buffalo, 14260, Buffalo, New York, USA

    D. J. Triggle, A. Skattebol, D. Rampe, A. Joslyn & P. Gengo

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  1. D. J. Triggle
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  2. A. Skattebol
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  3. D. Rampe
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  4. A. Joslyn
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  5. P. Gengo
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  1. Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

    George Poste  & Stanley T. Crooke  & 

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© 1986 Plenum Press, New York

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Triggle, D.J., Skattebol, A., Rampe, D., Joslyn, A., Gengo, P. (1986). Chemical Pharmacology of Ca2+ Channel Ligands. In: Poste, G., Crooke, S.T. (eds) New Insights into Cell and Membrane Transport Processes. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5062-0_7

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  • DOI: https://doi.org/10.1007/978-1-4684-5062-0_7

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