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Uptake and Intracellular Processing of Cell Surface Receptors

Current Concepts and Prospects

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New Insights into Cell and Membrane Transport Processes

Part of the book series: New Horizons in Therapeutics ((NHTH))

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Abstract

Uptake of macromolecules at the cell surface is an essential function that occurs in all eucaryotic cells at some stage in their lifetime. It can be achieved by a variety of processes, but all of them probably involve the invagination and subsequent pinching off of a localized segment of the plasma membrane to form an intracellular vesicle. This form of uptake is readily observed in living cells during phagocytosis and pinocytosis, but these are activities found only in certain specialized cell types. The most widespread form of endocytosis occurs below the resolution limit of the light microscope, where profiles observed by electron microscopy suggest that invaginations in the size range 50–200 nm are responsible. This form of uptake, generally referred to as “micropinocytosis,” certainly includes a variety of processes that differ in their selectivity and purpose. Tracer studies suggest that the processes of micropinocytic uptake are responsible for a steady, continuous rate of internalization that, in cultured fibroblasts, for example, internalizes less than 50% of the plasma membrane every hour (Steinman et al., 1976, 1983).

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References

  • Abrahamson, D. R., and Rodewald, R., 1981, Evidence for the sorting of endocytic vesicle contents during the receptor-mediated transport of IgG across the newborn rat intestine, J. Cell. Biol. 91:270–280.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, R. G. W., and Kaplan, J., 1983, Receptor mediated endocycosis, in: Modem Cell Biology (B. Satir, ed.), Alan R. Liss, New York, pp. 1–52.

    Google Scholar 

  • Anderson, R. G. W., Brown, M. S., Beisiegel, U., and Goldstein, J. L., 1982, Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies, J. Cell Biol. 93:523–531.

    Article  PubMed  CAS  Google Scholar 

  • Basu, S. K., Goldstein, J. L., Anderson, R. G. W., and Brown, M. S., 1981, Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts. Cell 24:493–502.

    Article  PubMed  CAS  Google Scholar 

  • Beardmore, J., and Hopkins, C. R., 1983, Uptake and intracellular processing of epidermal growth factor receptor complexes, Biochem. Soc. Trans. 12:165–168.

    Google Scholar 

  • Beguinot, L., Lyall, R. M., Willingham, M. C., and Pastan, I., 1984, Down regulation ofthe epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes, Proc. Natl. Acad. Sci. U.S.A. 81:2384–2388.

    Article  PubMed  CAS  Google Scholar 

  • Besterman, J. M., Airhart, R. C., Woodworth, R. C., and Low, R. B., 1981, Exocytosis of pinocytosed fluid in cultured cells: Kinetic evidence for rapid turnover and compartmentation, J. Cell Biol. 91:716–727.

    Article  PubMed  CAS  Google Scholar 

  • Bloom, W. S., Fields, K. L., Yen, S. H., Haver, K., Schook, W., and Puszkin, S., 1980, Brain clathrin: Immunofluorescent patterns in cultured cells and tissues, Proc. Natl. Acad. Sci. U.S.A. 77:5520–5524.

    Article  PubMed  CAS  Google Scholar 

  • Bretscher, M. S., 1982, Endocycosis, the sorting problem and cell locomotion in fibroblasts, Ciba Found. Symp. 92:266–281.

    PubMed  Google Scholar 

  • Bretscher, M. S., 1984, Endocytosis: Relation to capping and cell locomotion. Science 226:681–685.

    Article  Google Scholar 

  • Bretscher, M. S., Thomson, J. N., and Pearse, B. M. F., 1980, Coated pits act as molecular filters, Proc. Natl. Acad. Sci. U.S.A. 77:4156–4159.

    Article  PubMed  CAS  Google Scholar 

  • Brown, K. D., Friedkin, M., and Rozengurt, E., 1980, Colchicine inhibits epidermal growth factor degradation in 3T3 cells, Proc. Natl. Acad. Sci. U.S.A. 77:480–484.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M. S., Anderson, R. G. W., and Goldstein, J. L., 1983, Recycling receptors: The round trip itinerary of migrant membrane proteins, Cell 32:663–667.

    Article  PubMed  CAS  Google Scholar 

  • Brown, W. J., and Farquhar, M. G., 1984, Accumulation of coated vesicles bearing mannose-6-phosphate receptors for lysosomal enzymes in the Golgi region of I cell fibroblasts, Proc. Natl. Acad. Sci. U.S.A. 81:5135–5139.

    Article  PubMed  CAS  Google Scholar 

  • Carpenter, G., 1984, Properties of the receptor for epidermal growth factor. Cell 37:357–358.

    Article  PubMed  CAS  Google Scholar 

  • Carpenter, G., and Cohen, S., 1979, Epidermal growth factor, Annu. Rev. Bioehem. 48:193–216.

    Article  CAS  Google Scholar 

  • Carpentier, J. L., Görden, P., Anderson, R. G. W., Goldstein, J. L., Brown, M. S., Cohen, S., and Orci, L., 1982, Co-locaHzation of epidermal growth factor and ferritin-low density lipoprotein in coated pits, J. Cell Biol. 95:73–77.

    Article  PubMed  CAS  Google Scholar 

  • Connolly, J. L., Green, S. A., and Greene, L. A., 1981, Pit formation and rapid changes in surface morphology of sympathetic neurones in response to nerve growth factor, J. Cell Biol. 90:176–180.

    Article  PubMed  CAS  Google Scholar 

  • Connolly, J. L., Green, S. A., and Greene, L. A., 1984, Comparison of rapid changes in surface morphology and coated pit formation of PC 12 cells in response to growth factor, epidermal growth factor and dibutryl cyclic AMP, J. Cell Biol. 98:457–465.

    Article  PubMed  CAS  Google Scholar 

  • Davies, P. F., and Ross, R., 1978, Mediation of pinocytosis in cultured arterial smooth muscle and endothehal cells by platelet derived growth factor, J. Cell Biol. 79:663–671.

    Article  PubMed  CAS  Google Scholar 

  • Debanne, M. T., Evans, W. H., Flint, N., and Regoeczi, E., 1982, Receptor-rich intracellular membrane vesicles transporting asialotransferrin and insulin in liver. Nature 298:398–400.

    Article  PubMed  CAS  Google Scholar 

  • Dickson, R. B., Beguinot, L., Hanover, J. A., Richert, N. D., Willingham, M. C., and Pastan, I., 1983, Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line, Proc. Natl. Acad. Sci. U.S.A. 80:5335–5339.

    Article  PubMed  CAS  Google Scholar 

  • Draper, R. K., and Simon, M. I., 1980, The entry of diptheria toxin into the mammalian cell cytoplasm: Evidence for lysosomal involvement, J. Cell Biol. 87:849–854.

    Article  PubMed  CAS  Google Scholar 

  • Dunn, W. A., Hubbard, A. L., and Aronson, N. N., Jr., 1980, Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of asialofetuin by perfused rat liver, J. Biol. Chem. 255:5971–5978.

    PubMed  CAS  Google Scholar 

  • Galloway, C. J., Dean, G. E., Marsh, M., Rudnick, C., and Mellman, L, 1983, Acidification of macrophage and fibroblast endocytic vesicles in vitro, Proc. Natl. Acad. Sci. U.S.A. 80:3334–3338.

    Article  PubMed  CAS  Google Scholar 

  • Geisow, M. J., and Evans, W. H., 1984, pH in the endosome, Exp. Cell Res. 150:36–46.

    Article  PubMed  CAS  Google Scholar 

  • Geuze, H. J., Slot, J. W., Strous, G. J. A. M., Lodish, H. F., and Schwartz, A. L., 1983, Intracellular site of asialoglycoprotein receptor ligand uncoupling: Double-label immunoelectron microscopy during receptor mediated endocytosis. Cell 32:277–287.

    Article  PubMed  CAS  Google Scholar 

  • Geuze, H. J., Slot, J. W., Strous, G. J. A. M., Peppard, J., van Figura, K., Hasilik, A., and Schwartz, A. L., 1984, Intracellular receptor sorting during endocytosis: Comparative immunoelectron microscopy of multiple receptors in rat hver. Cell 37:195–204.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, J. L., Anderson, R. G. W., and Brown, M. S., 1979, Coated pits, coated vesicles and receptor-mediated endocytosis. Nature 279:679–685.

    Article  PubMed  CAS  Google Scholar 

  • Gonatas, N. K., Stieber, A., Hickey, W. F., Herbert, S. H., and Gonatas, J. O., 1984, Endosomes and Golgi vesicles in absorptive and fluid phase endocytosis, J. Cell Biol. 99:1379–1390.

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez Noriega, A., Grubb, J. H., Talkad, V., and Sly, W. S., 1980, Chloroquine inhibits lysosomal pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling, J. Cell Biol. 85:839–852.

    Article  PubMed  CAS  Google Scholar 

  • Görden, P., Carpentier, J. L., Freychet, P., and Orci, L., 1980, Internalization of polypeptide hormones: Mechanism, intracellular localization and significance, Diabetalogia 18:263–274.

    Article  Google Scholar 

  • Gould, B., Huet, C., and Louvard, D., 1985, Assembled and unassembled pools of clathrin: A quantitative study using an enzyme immunoassay, J. Cell Biol, (in press).

    Google Scholar 

  • Haigler, H. T., McKanna, J. A., and Cohen, S., 1979, Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor, J. Cell Biol. 83:82–90.

    Article  PubMed  CAS  Google Scholar 

  • Harikumar, P., and Reeves, J. P., 1983, The lysosomal proton pump is electrogenic, J. Biol. Chem. 258:10403–10410.

    PubMed  CAS  Google Scholar 

  • Helenius, A., and Marsh, M., 1982, Endocytosis of enveloped animal viruses, Ciba Found. Symp. 92:59–76.

    PubMed  CAS  Google Scholar 

  • Helenius, A., Mellman, L, Wall, D., and Hubbard, A., 1983, Endosomes, Trends Biochem. Sci. 8:245–250.

    Article  CAS  Google Scholar 

  • Heuser, J., and Evans, L., 1980, Three dimensional visualization of coated vesicle formation in fibroblasts, J. Cell Biol. 84:560–583.

    Article  PubMed  CAS  Google Scholar 

  • Hopkins, C. R., 1983a, The importance of the endosome in intracellular traffic. Nature 304:684–685.

    Article  PubMed  CAS  Google Scholar 

  • Hopkins, C. R., 1983b, Intracellular routing of transferrin and transferring receptors in epidermoid carcinoma A431 cells. Cell 35:321–330.

    Article  PubMed  CAS  Google Scholar 

  • Hopkins, C. R., 1985, Appearance of transferrin receptors at the leading edge of epidermoid carcinoma cells, Cell (in press).

    Google Scholar 

  • Hopkins, C. R., and Trowbridge, I. S., 1983, Internalization and processing of transferrin and the transferring receptor in human carcinoma A431 cells, J. Cell Biol. 97:508–521.

    Article  PubMed  CAS  Google Scholar 

  • Hopkins, C. R., Boothroyd, B., and Gregory, H., 1981, Early events following the binding of epidermal growth factor to surface receptors on ovarian granulosa cells, Eur. J. Cell Biol. 24:259–265.

    PubMed  CAS  Google Scholar 

  • Huet, C., Ash, C., and Singer, S. J., 1980, The antibody induced clustering and endocytosis of HLA antigens on cultured human fibroblasts. Cell 21:429–438.

    Article  PubMed  CAS  Google Scholar 

  • Hunter, T., and Cooper, J. A., 1981, Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell 24:741–752.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, J., and Keogh, E. A., 1981, Analysis of the effect of amines on inhibition of receptor-mediated and fluid phase pinocytosis in rabbit alveolar macrophages. Cell 24:925–932.

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki, D., Noronha-Blob, L., Sacktor, B., and Farquhar, M. G., 1984, Microdomains of distinctive glycoprotein composition in the kidney proximal tubule brush border, 98:1505–1513.

    CAS  Google Scholar 

  • Kielian, M. D., and Helenius, A., 1984, Role of cholesterol in fusion of Semliki Forest virus with membranes, J. Virol 52:281–283.

    PubMed  CAS  Google Scholar 

  • Klausner, R. D., Harford, J., and van Renswoude, J., 1984, Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester, Proc. Natl. Acad. Sci. U.S.A. 81:3005–3009.

    Article  PubMed  CAS  Google Scholar 

  • Lamb, J. E., Ray, F., Ward, J. H., Kushner, J. P., and Kaplan, J., 1983, Internalization and subcellular localization of transferrin and transferrin receptors in He La cells, J. Biol. Chem. 258:8751–8758.

    PubMed  CAS  Google Scholar 

  • Levine, J. S., Allen, R. H., Alpers, D. H., and Seetharam, B., 1984, Immunocytochemical localization of the intrinsic factor-cobalamin receptor in dog ileum: Distribution of the intracellular receptor during cell maturation, J. Cell Biol. 98:1111–1118.

    Article  PubMed  CAS  Google Scholar 

  • McKanna, J. A., Haigler, H. T., and Cohen, S., 1979, Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factor, Proe. Natl. Aead. Sci. U.S.A. 76:5689–5693.

    Article  CAS  Google Scholar 

  • Merion, M., Schlessinger, P., Brooks, R. M., Moehring, J. M., Moehring, T. J., and Sly, W. S., 1983, Defective acidification of endosomes in Chinese hamster cell mutants “cross resistant” to toxins and viruses, Proe. Natl. Aead. Sci. U.S.A. 80:5315–5319.

    Article  CAS  Google Scholar 

  • Miskimins, W. K., and Shimizu, N., 1984, Uptake of epidermal growth factor into a lysosomal enzyme deficient organelle: Correlation with cell’s mitogenic response and evidence for ubiquitous existence in fibroblasts, J. Cell. Physiol. 118:305–316.

    Article  PubMed  CAS  Google Scholar 

  • Mroczkowski, B., Mosig, G., and Cohen, S., 1984, ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA, Nature 309:270–273.

    Article  PubMed  CAS  Google Scholar 

  • Mullock, B. M., and Hinton, R. H., 1981, Transport of proteins from blood to bile. Trends Bioehem. Sci. 6:188–191.

    Article  CAS  Google Scholar 

  • Nagura, H., Nakane, P. K., and Brown, W. R., 1979, Translocation of dimeric IgA through neoplastic colon cells in vitro, J. Immunol. 123:2359–2368.

    PubMed  CAS  Google Scholar 

  • Pearse, B. M. F., 1982, Structure of coated pits and vesicles, Ciba Found. Symp. 92:246–280.

    PubMed  Google Scholar 

  • Pearse, B. M. F., and Bretscher, M. S., 1981, Membrane recycling by coated vesicles, Annu. Rev. Bioehem. 50:85–101.

    Article  CAS  Google Scholar 

  • Quintart, J., Courtoy, P. J., and Baudhin, P., 1984, Receptor-mediated endocytosis in rat liver: Purification and enzymic characterization of low density organelles involved in uptake of galactose-exposing proteins, J. Cell Biol. 98:877–884.

    Article  PubMed  CAS  Google Scholar 

  • Renswoude, J., Bridges, K. R., Harford, J. B., and Klausner, R. D., 1982, Receptor-mediated endocytosis of transferrin and uptake of Fe in K562 cells, Proe. Natl. Acad. Sci. U.S.A. 79:6186–6190.

    Article  Google Scholar 

  • Rindler, M. J., Ivanov, I. E., Plesben, H., Rodriguez-Boulan, E., and Sabatini, D. D., 1984, Viral glycoproteins destined for apical or basolateral plasma membrane domains traverse the same Golgi apparatus during their intracellular transport in doubly infected Madin-Darby canine kidney cells, J. Cell Biol. 98:1304–1319.

    Article  PubMed  CAS  Google Scholar 

  • Sly, W. S., and Fischer, H. D., 1982, The phosphomannosyl recognition system for intracellular and intercellular transport of lysosomal enzymes, J. Biol. Chem. 18:67–85.

    CAS  Google Scholar 

  • Steinman, R. M., Brodie, S. E., and Cohn, Z. A., 1976, Membrane flow during pinocytosis, J. Cell Biol. 68:665–687.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., Mellman, I. S., Muller, W. A., and Cohn, Z. A., 1983, Endocytosis and recycling of plasma membrane, J. Cell Biol. 96:1–27.

    Article  PubMed  CAS  Google Scholar 

  • Stone, D. K., Xie, X.-S., and Racker, E., 1983, An ATP-driven proton pump in clathrin coated vesicles, J. Biol. Chem 258:4059–4062.

    PubMed  CAS  Google Scholar 

  • Stoscheck, C. M., and Carpenter, O., 1984, Down-regulation of epidermal growth factor receptors: Direct demonstration of receptor degradation in human fibroblasts, J. Cell Biol. 98:1048–1053.

    Article  PubMed  CAS  Google Scholar 

  • Stossel, T. P., and Hartwig, J. H., 1976, Interactions of actin, myosin, and a new actin-binding protein in rabbit pulmonary macrophages II: Role in cytoplasmic movement and phagocytosis, J. Cell Biol. 68:602–619.

    Article  PubMed  CAS  Google Scholar 

  • Stratford-May, W., Jacobs, S., and Cuatrecasas, P., 1984, Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells, Proc. Natl. Acad. Sci. U.S.A. 81:2016–2020.

    Article  Google Scholar 

  • Ullrich, A., Coussens, L., Hayflick, J. S., Dull, T. J., Gray, A., Tam, A. W., Lee, J., Yarden, Y., Libermann, T. A., Schlessinger, J., Downward, J., Mayes, E. L., Whittle, N., Waterfield, M. D., and Seeburg, P. H., 1984, Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309:418–425.

    Article  PubMed  CAS  Google Scholar 

  • Valerius, N. H., Stendahl, O., Hartwig, J. H., and Stossel, T. P., 1981, Distribution of actin binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis. Cell 24:195–202.

    Article  PubMed  CAS  Google Scholar 

  • van Dyke, R. W., Steer, C. J., and Scharschmidt, B. F., 1984, Clathrin-coated vesicles from rat liver: Enzymatic profile and characterization of ATP-dependent proton transport, Proc. Natl. Acad. Sci. U.S.A. 81:3108–3112.

    Article  PubMed  Google Scholar 

  • Via, D. P., Willingham, M. C., Pastan, I., Gotto, A. M., Jr., and Smith, L. C., 1982, Co-clustering and internalization of low density lipoproteins and alpha2 macroglobulin in human skin fibroblasts, Exp. Cell Res. 141:15–22.

    Article  PubMed  CAS  Google Scholar 

  • Wall, D. A., Wilson, G., and Hubbard, A. L., 1980, The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes. Cell 21:79–93.

    Article  PubMed  CAS  Google Scholar 

  • Watts, C., 1985, Rapid endocytosis of the transferrin receptor in the absence of bound transferrin, J. Cell Biol, (in press).

    Google Scholar 

  • White, J., Kieliman, M., and Helenius, A., 1983, Membrane fusion proteins of animal enveloped viruses, Q. Rev. Biophys. 16:151–195.

    Article  PubMed  CAS  Google Scholar 

  • Willingham, M. C., and Pastan, I. H., 1982, Transit of epidermal growth factor through coated pits of the Golgi system, J. Cell Biol. 94:207–212.

    Article  PubMed  CAS  Google Scholar 

  • Willingham, M. C., and Pastan, I. H., 1984, Do coated vesicles exist? Trends Biochem. Sci. 9:93–94.

    Article  Google Scholar 

  • Willingham, M. C., Haigler, H. T., Fitzgerald, D. J. P., Gallo, M. G., Rutherford, A. V., and Pastan, I. H., 1983, The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells, Exp. Cell Res. 146:163–175.

    Article  PubMed  CAS  Google Scholar 

  • Willingham, M. C., Hanover, J. A., Dickson, R. B., and Pastan, I. H., 1984, Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells, Proc. Natl. Acad. Sci. U.S.A. 81:175–179.

    Article  PubMed  CAS  Google Scholar 

  • Wolkoff, A. W., Klausner, R. D., Ashwell, G., and Harford, J., 1984, Intracellular segregation of asialoglycoproteins and their receptor: A prelysosomal event subsequent to dissociation of ligand receptor complex, J. Cell Biol. 98:375–381.

    Article  PubMed  CAS  Google Scholar 

  • Yamashiro, D. J., Fluss, S. R., and Maxfield, F. R., 1983, Acidification of endocytic vesicles by an ATP-dependent proton pump, J. Cell Biol. 97:929–934.

    Article  PubMed  CAS  Google Scholar 

  • Yamashiro, D. J., Tycko, B., Fluss, S. R., and Maxfield, F. R., 1984, Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway. Cell 37:789–800.

    Article  PubMed  CAS  Google Scholar 

  • Zidovetzki, R., Yarden, Y., Schlessinger, J., and Jovin, T. M., 1981, Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors, Proc. Natl. Acad. Sci. U.S.A. 78:6981–6985.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Medical Cell Biology, University of Liverpool, Liverpool, L69 3BX, England

    Colin R. Hopkins

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  1. Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

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Hopkins, C.R. (1986). Uptake and Intracellular Processing of Cell Surface Receptors. In: Poste, G., Crooke, S.T. (eds) New Insights into Cell and Membrane Transport Processes. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5062-0_18

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