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Analysis of Epithelial Cell Surface Polarity Development with Monoclonal Antibodies

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New Insights into Cell and Membrane Transport Processes

Part of the book series: New Horizons in Therapeutics ((NHTH))

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Abstract

The cells of transporting epithelia are organized into either sheets or tubules so that they provide a barrier between two compartments, the mucosal and serosal, which are essential for the proper physiological functioning of a variety of organs and tissues. The plasma membrane of epithelial cells is divided into two unique domains: the apical membrane, which borders the mucosal or luminal side, and the basolateral membrane, which contacts the basal lamina on the serosal side of the epithelium (Berridge and Oschman, 1972). At the boundary between the apical and basolateral domains is a differentiated region of the plasma membrane termed the junctional complex (Farquhar and Palade, 1963), and one of these membrane specializations, the tight junction, seals the lateral space, preventing the transepithelial movement of ions and larger molecules (Farquhar and Palade, 1963; Staehelin, 1974).

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, 11203, Brooklyn, New York, USA

    George K. Ojakian

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  1. George K. Ojakian
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Editors and Affiliations

  1. Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

    George Poste  & Stanley T. Crooke  & 

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© 1986 Plenum Press, New York

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Ojakian, G.K. (1986). Analysis of Epithelial Cell Surface Polarity Development with Monoclonal Antibodies. In: Poste, G., Crooke, S.T. (eds) New Insights into Cell and Membrane Transport Processes. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5062-0_15

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  • DOI: https://doi.org/10.1007/978-1-4684-5062-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5064-4

  • Online ISBN: 978-1-4684-5062-0

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