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Hormone-Induced Inositol Lipid Breakdown and Calcium-Mediated Cellular Responses in Liver

  • Chapter
New Insights into Cell and Membrane Transport Processes

Part of the book series: New Horizons in Therapeutics ((NHTH))

Abstract

Although it has been recognized for many years that changes of the intracellular free Ca2+ concentration by a variety of agonists form an important signaling device for regulation of cell function, the source of the Ca2+ and the molecular events regulating receptor-mediated changes of cellular calcium homeostasis have remained recalcitrant problems despite much effort directed towards their elucidation. However, advances made along a number of different lines have contributed towards the rapid increase of knowledge in this area. These include on the one hand the development of fluorescent Ca2+ indicators such as Quin 2 (Tsien, 1983) and more recently Fura 2 (Grynkiewicz et al., 1985), which allow kinetic measurements of changes in the cytosolic free Ca2+ concentration of isolated cells, and on the other hand the elucidation of the signaling roles of two new intracellular second messengers, namely, inositol trisphosphate and diacylglycerol (for reviews see Nishizuka et al., 1984; Nishizuka, 1984a; Berridge and Irvine, 1984; Williamson et al., 1985; Williamson, 1986).

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania, USA

    John R. Williamson, Suresh K. Joseph, Kathleen E. Coll, Andrew P. Thomas, Arthur Verhoeven & Marc Prentki

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  1. John R. Williamson
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  2. Suresh K. Joseph
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  3. Kathleen E. Coll
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  4. Andrew P. Thomas
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  5. Arthur Verhoeven
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  6. Marc Prentki
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  1. Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

    George Poste  & Stanley T. Crooke  & 

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© 1986 Plenum Press, New York

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Williamson, J.R., Joseph, S.K., Coll, K.E., Thomas, A.P., Verhoeven, A., Prentki, M. (1986). Hormone-Induced Inositol Lipid Breakdown and Calcium-Mediated Cellular Responses in Liver. In: Poste, G., Crooke, S.T. (eds) New Insights into Cell and Membrane Transport Processes. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5062-0_11

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  • DOI: https://doi.org/10.1007/978-1-4684-5062-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5064-4

  • Online ISBN: 978-1-4684-5062-0

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