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Aging of Adrenal Cortex and Ovary

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Aging, Reproduction, and the Climacteric
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Abstract

The early impetus to study hormone secretion in aging resulted from attempts to understand the failing libido noted in many older men. The topic has been investigated and reinvestigated as methods improved, from crude bioassays to crude steroid measurements (the 17-ketosteroids) arriving finally at our present level of sophistication in hormone analysis. Nevertheless, even the semiquantitative bioassays and the gross group measurements of steroids revealed the basic outlines of aging in the adrenal cortex and ovary.

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References

  • Albertson, B. D., Hobson, W. C., Burnett, B. S., Turner, P. T., Clark, R. V., Schiebinger, R. J., Loriaux, D. L., and Cutler, G. B., Jr., 1984, Dissociation of cortisol and adrenal androgen secretion in the hypophysectomized, adreno-corticotropin-replaced chimpanzee, J. Clin. Endrocrinol. Metab. 59:13–18.

    Article  CAS  Google Scholar 

  • Blaha, G. C., 1970, The influence of ovarian grafts from young donors on the development of transferred ova in aged golden hamsters, Fertil. Steril. 21:268–273.

    PubMed  CAS  Google Scholar 

  • Casey, M. L. and MacDonald, P. C., 1983, Origin of estrogen and regulation of its formation in postmenopausal women, in The Menopause (H. J. Buchsbaum, ed.), Springer-Verlag, New York, pp. 1–8.

    Chapter  Google Scholar 

  • Coleman, D. L., Leiter, E. H., and Schwizer, R. W., 1983, Therapeutic effects of dehydroepian-drosterone (DHEA) in diabetic mice, Diabetes 31:830–833.

    Article  Google Scholar 

  • Costoff, A., and Mahesh, V. B., 1975, Primordial follicles with normal oocytes in the ovaries of postmenopausal women, J. Am. Geriatr. Soc. 23:193–197.

    PubMed  CAS  Google Scholar 

  • Cumming, D. C., Rebar, R. W., Hopper, B. R., and Yen, S. S. C., 1982, Evidence for an influence of the ovary on circulating dehydroepiandrosterone sulfate levels, J. Clin. Endocrinol. Metab. 54:1069–1071.

    Article  PubMed  CAS  Google Scholar 

  • Grodin, J. M., Siiteri, P. K., and MacDonald, P. C., 1973, Source of estrogen production in postmenopausal women, J. Clin. Endocrinol. Metab. 36:207–214.

    Article  PubMed  CAS  Google Scholar 

  • Hauffa, B. P., Kaplan, S. L., and Grumbach, M. M., 1984, Dissociation between plasma adrenal androgens and cortisol in Cushing’s disease and ectopic ACTH-producing tumor: Relation to adrenarche, Lancet 1:1373–1376.

    Article  PubMed  CAS  Google Scholar 

  • Judd, H. L., 1976, Hormonal dynamics associated with the menopause, Clin. Obstet. Gynecol. 19:775–788.

    Article  PubMed  CAS  Google Scholar 

  • Judd, H. L., Davidson, B. J., Freeman, A. M., Shamonk, I. M., Lagasse, L. D., and Ballon, S. C., 1980, Serum androgens and estrogens in postmenopausal women with and without endometrial cancer, Am. J. Obstet. Gynecol. 136:859–871.

    PubMed  CAS  Google Scholar 

  • Krohn, P. L., 1962, Heterochronic transplantation in the study of ageing, Proc. R. Soc. Lond. (Biol.) 157:128–147.

    Article  CAS  Google Scholar 

  • Lobo, R. A., March, C. M., Goebelsmann, O., and Mishell, D. R., Jr., 1982, The modulating role of obesity and 17 β-estradiol (E2) on bound and unbound E2 and adrenal androgens in oophorectomized women, J. Clin. Endocrinol. Metab. 54:320–324.

    Article  PubMed  CAS  Google Scholar 

  • Longcope, C., 1971, Metabolic clearance rates of estrogens in postmenopausal women, Am. J. Obstet. Gynecol. 111:778–781.

    PubMed  CAS  Google Scholar 

  • Longcope, C., Hunter, R., and Franz, C., 1980, Steroid secretion by the postmenopausal ovary, Am. J. Obstet. Gynecol. 138:564–568.

    PubMed  CAS  Google Scholar 

  • Lucky, A. W., Marynick, S. P., Rebar, R. W., Cutler, G. B., Glen, M., Johnsonbaugh, E., and Loriaux, D. L., 1979, Replacement oral ethynylestradiol therapy for gonadal dysgenesis: Growth and adrenal androgen studies, Acta Endocrinol. (Copenh) 91:519–524.

    CAS  Google Scholar 

  • Meldrum, D. R., Davidson, B. J., Tataryn, I. V., and Judd, H. L., 1981, Changes in circulating steroids with aging in postmenopausal women, Obstet. Gynecol. 57:624–628.

    PubMed  CAS  Google Scholar 

  • Parker, L. N., and Odell, W. D., 1979, Evidence for existence of cortical androgen-stimulating hormone, Am. J. Physiol. E616-E620.

    Google Scholar 

  • Parker, L. N., Lifrak, E. T., and Odell, W. D., 1983, A 60, 000 molecular weight human pituitary glycopeptide stimulate adrenal androgen secretion, Endocrinology 113:2092–2096.

    Article  PubMed  CAS  Google Scholar 

  • Paschko, L. L., Rovito, R. J., Williams, J. R., Sobel, E. L., and Schwartz, A. G., 1984, Dehydroepiandrosterone (DHEA) and 3 β-methylandrost-5-en-17-one: inhibitors of 7, 12-demethylbenz [a]-anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin papilloma formation in mice, Carcinogenesis 5:463–466.

    Article  Google Scholar 

  • Pincus, G., Dorfman, R. I., Romanoff, L. P., Rubin, B. L., Bloch, E., Carlo, J., and Freeman, H., 1955, Steroid metabolism in aging men and women, Recent Prog. Hormone Res. 11:307–334.

    Google Scholar 

  • Schwartz, N. B., and Hunzicker-Dunn, M., 1981, Dynamics of Ovarian function, Raven Press, New York, Chapters 1-7.

    Google Scholar 

  • Sherman, M. B., West, J. H., and Korenman, S. G., 1976, The menopausal transition: Analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women, J. Clin. Endocrinol. Metab. 42:629–636.

    Article  PubMed  CAS  Google Scholar 

  • Talbert, G. B., 1978, Effect of aging of the ovaries and female gametes on reproductive capacity, in The Aging Reproductive System, Vol. 4 (E. L. Schneider, ed.), Raven Press, New York.

    Google Scholar 

  • Vermeulen, A., 1976, The hormonal activity of the postmenopausal ovary, J. Clin. Endocrinol. Metab. 42:247–253.

    Article  PubMed  CAS  Google Scholar 

  • Vermeulen, A., Deslypere, J. P., Schelfhrout, W., Verdonck, L., and Rubens, R., 1982, Adre-nocortical function in old age. Response to acute adrenocorticotropin stimulation, J. Clin. Endocrinol. Metab. 54:187–191.

    Article  PubMed  CAS  Google Scholar 

  • Yen, T. T., Allan, J. V., Pearson, D. V., Acton, J. M., and Greenberg, M., 1977, Prevention of obesity in Avy/a mice by dehydroepiandrosterone, Lipids 12:409–413.

    Article  PubMed  CAS  Google Scholar 

  • Zuckerman, S., 1951, The number of oocytes in the mature ovary, Recent Prog. Hormone Res. 6:63–84.

    Google Scholar 

  • Zumoff, B., Rosenfeld, R. S., Strain, G. W., Levin, J., and Fukushima, D. K., 1980, Sex differences in the twenty-four-hour mean plasma concentrations of dehydroisoandrosterone and de-hydroisoandrosterone sulfate (DHAS) and the DHA to DHAS ratio in normal adults, J. Clin. Endocrinol. Metab. 51:330–333.

    Article  PubMed  CAS  Google Scholar 

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© 1986 Plenum Press, New York

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Lipsett, M.B. (1986). Aging of Adrenal Cortex and Ovary. In: Mastroianni, L., Paulsen, C.A. (eds) Aging, Reproduction, and the Climacteric. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5047-7_5

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  • DOI: https://doi.org/10.1007/978-1-4684-5047-7_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5049-1

  • Online ISBN: 978-1-4684-5047-7

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