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Immunohistochemistry

  • Chapter
Regulation of Hepatic Metabolism

Abstract

Knowledge of the precise intratissue and intracellular localizations and distributions of enzymes and other biological molecules is often a prerequisite for understanding the metabolic and regulatory functions of these substances. Such information is also frequently required for defining the biological functions of specific cells and for elucidating the underlying biochemical bases for any differences in metabolic capabilities that may exist among morphologically different cell types as well as among morphologically similar cells. Unfortunately, the acquisition of this information is frequently hindered by a number of factors that include, but are not necessarily limited to, the presence of low tissue and/or cellular levels and/or activities of enzymes and other biological molecules and the fact that mammalian tissues are not composed of a single, homogeneous population of cells. In this respect, although the liver is commonly considered to be a fairly homogeneous tissue, it must be appreciated that significant differences in biochemical and physiological characteristics and functions have frequently been detected among hepatic parenchymal cells, or hepatocytes. A number of these differences are considered in greater detail in Sections III and IV of this volume.

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Authors and Affiliations

  1. The Toxicology Center, Department of Pharmacology, The University of Iowa College of Medicine, Iowa City, Iowa, 52242, USA

    Jeffrey Baron, Jeffrey M. Voigt, Thomas T. Kawabata & Jan A. Redick

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  1. Jeffrey Baron
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  2. Jeffrey M. Voigt
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  3. Thomas T. Kawabata
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  4. Jan A. Redick
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Editors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27514, USA

    Ronald G. Thurman

  2. Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland, 21202, USA

    Frederick C. Kauffman

  3. Georg-August Universität, Göttingen, Federal Republic of Germany

    Kurt Jungermann

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© 1986 Plenum Press, New York

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Baron, J., Voigt, J.M., Kawabata, T.T., Redick, J.A. (1986). Immunohistochemistry. In: Thurman, R.G., Kauffman, F.C., Jungermann, K. (eds) Regulation of Hepatic Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5041-5_4

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  • DOI: https://doi.org/10.1007/978-1-4684-5041-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5043-9

  • Online ISBN: 978-1-4684-5041-5

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