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Lobular Oxygen Gradients: Possible Role in Alcohol-Induced Hepatotoxicity

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Regulation of Hepatic Metabolism

Abstract

Alcoholic liver disease is a major health problem, and specific therapies are lacking because we still do not understand how alcohol causes liver damage. The purpose of this chapter is to evaluate the evidence for and against the hypothesis that hypoxia is involved in this disease. We shall review hepatic oxygen uptake, ethanol metabolism and adaptations, and hypoxic tissue damage in general briefly.

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27514, USA

    Ronald G. Thurman & Sungchul Ji

  2. Department of Anatomy, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27514, USA

    John J. Lemasters

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  1. Ronald G. Thurman
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  2. Sungchul Ji
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  3. John J. Lemasters
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Editors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27514, USA

    Ronald G. Thurman

  2. Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland, 21202, USA

    Frederick C. Kauffman

  3. Georg-August Universität, Göttingen, Federal Republic of Germany

    Kurt Jungermann

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© 1986 Plenum Press, New York

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Thurman, R.G., Ji, S., Lemasters, J.J. (1986). Lobular Oxygen Gradients: Possible Role in Alcohol-Induced Hepatotoxicity. In: Thurman, R.G., Kauffman, F.C., Jungermann, K. (eds) Regulation of Hepatic Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5041-5_12

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  • DOI: https://doi.org/10.1007/978-1-4684-5041-5_12

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