Skip to main content

Diagnosis and Treatment of Malignant Lymphomas in the Elderly

  • Chapter
  • 75 Accesses

Part of the book series: Contemporary Geriatric Medicine ((COGM,volume 2))

Abstract

The process of aging is associated with structural and functional changes occurring in the living organism and often expressed in gradual deterioration and decline in performance. These impairments result in changes in host resistance and are perhaps the major factors in the emergence of neoplasia in those elderly who have survived the ravages of vascular diseases, accidents, and infection. The hematologic neoplasms are generally diseases of higher incidence with advancing age. These disorders are uncommon under the age of 40; although they do not represent a national health hazard, they are not rare. Malignant lymphomas have an incidence of 82 cases per million. The occurrence of the lymphomas and the ability of the host to deal with them as well as responses to therapy are all modified by advanced age and will be discussed in this chapter.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Mackay, R. R., 1972, Aging and immunologic function in man, Gerontologia 18: 285.

    Article  PubMed  CAS  Google Scholar 

  2. Diaz-Jouanen, E., Strickland, R., and Williams, S. R., 1975, Studies of human lymphocytes in the new born and the aged, Am. J. Med. 58: 620.

    Article  Google Scholar 

  3. Young, R. C., Corder, M. P., and Haynes, H. A., 1972, Delayed hypersensitivity in Hodgkin’s disease: A study of 103 patients, Am. J. Med. 52: 63–71.

    Article  PubMed  CAS  Google Scholar 

  4. Jones, S. E., Griffith, K., and Dombrowski, P., 1977, Immunodeficiency in patients with non-Hodgkin’s lymphoma, Blood 49: 335–344.

    PubMed  CAS  Google Scholar 

  5. Moore, D. F., Migliore, P. H., and Shullenberger, C. C., 1970, Moncoclonal macroglobulinemia in malignant lymphoma, Ann. Intern. Med. 72: 43.

    PubMed  CAS  Google Scholar 

  6. MacMahon, B., 1957, Epidemiologic evidence on the nature of Hodgkin’s disease, Cancer 10: 1045–1054.

    Article  PubMed  CAS  Google Scholar 

  7. Greco, R. S., Acheson, R. S., and Foote, F. M., 1974, Hodgkin’s disease in Connecticut from 1935 to 1962: The bimodal incidence curve in the general population and survival in untreated patients, Arch. Intern. Med. 134: 1039–1042.

    CAS  Google Scholar 

  8. Newell, G. R., Cole, S. R., Miettinen, O. S., and MacMahon, B., 1970, Age differences in the histology of Hodgkin’s disease, J. Nat. Cancer, Inst. 45: 311–317.

    Google Scholar 

  9. Lokich, J. J., Pinkus, G. S., and Moloney, W. C., 1974, Hodgkin’s disease in the elderly, Oncology 29: 484–500.

    Article  PubMed  CAS  Google Scholar 

  10. Goodman, R. L., Piro, A. J., and Hellman, S., 1976, Can pelvic irradiation be omitted in patients with pathologic stages IA and IIA Hodgkin’s disease? Cancer 37: 2834–2839.

    Article  PubMed  CAS  Google Scholar 

  11. Hellman, S., 1979, An evaluation of total nodal irradiation as treatment for stage IIIA Hodgkin’s disease, Cancer 43: 1255–1261.

    Article  PubMed  Google Scholar 

  12. DeVita, V. T., Hubbard, S. M., Moxley, J. H., Ill, 1983, The Cure of Hodgkin’s Disease with Drugs, yearbook Medical Publishers, Inc., Chicago, pp. 277–301.

    Google Scholar 

  13. Bonadonna, G., Santoro, A., Bonfante, V., and Valagussa, P., 1982, Cyclic delivery of MOOP and ABVD combinations in stage IV Hodgkin’s disease: Rationale, background studies and recent results, Cancer Treat Rep 66: 881–887.

    PubMed  CAS  Google Scholar 

  14. Penn, I., 1975, The incidence of malignancies in transplant recipients, Transplant Proc 7: 323–326.

    PubMed  CAS  Google Scholar 

  15. Jones, S. E., Fuks, Z., Bull, M., Kadin, M. E., Dorfman, R. F., Kaplan, H. S., Rosenberg, S. A., and Kim, H., 1973, Non-Hodgkin’s lymphomas IV. Clinico pathological correlation in 405 cases Cancer 31: 806–823.

    CAS  Google Scholar 

  16. Jones, S. E., Fuks, A., Kaplan, H. S., and Rosenberg, S. A., 1973, Non-Hodgkin’s lymphomas. V. Results of radiotherapy, Cancer 32: 682–691.

    Article  PubMed  CAS  Google Scholar 

  17. Berard, C. W, Greene, M. H., Jaffe, E. S, Magrath, I, and Ziegler, J., 1981, NIH conference. A multi disciplinary approach to non-Hodgkin’s lymphomas, Ann. Intern. Med. 94 (2): 218–235.

    PubMed  CAS  Google Scholar 

  18. Portlock, C. S., and Rosenberg, S. A., 1979, No initial therapy for stage III and IV non-Hodgkin’s lymphomas of favourable histologic types, Ann. Intern. Med. 90: 10–13.

    PubMed  CAS  Google Scholar 

  19. Canellos, G. P., Skarin, A. T., and Rosenthal, D. S., 1981, Methotrexate as a single agent in combination chemotherapy for the treatment of non-Hodgkin’s lymphomas of unfavourable histology, Cancer Treat Rep. 65 (Suppl. 1): 125–129.

    PubMed  Google Scholar 

  20. Armitage, J. O., and Potter, J. F., 1984, Aggressive chemotherapy for diffuse histiocytic lymphoma in the elderly: Increased complications with advancing age, J. Am. Geriatr. Soc. 32: 269–273.

    PubMed  CAS  Google Scholar 

  21. Case, D. C., Jr., Lee, B. J., II, and Clarkson, B. D., 1977, Improved survival times in multiple myeloma treated with melphalan, prednisone, cyclophosphamide, vincristine, BCNU: M2 protocol, Am. J. Med. 63: 897–903.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Publishing Corporation

About this chapter

Cite this chapter

Gaddipati, J.C., Friedland, M.L., Arlin, Z. (1986). Diagnosis and Treatment of Malignant Lymphomas in the Elderly. In: Gambert, S.R. (eds) Contemporary Geriatric Medicine. Contemporary Geriatric Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5000-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5000-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5002-6

  • Online ISBN: 978-1-4684-5000-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics