Skip to main content

Geriatric Cardiology and Blood Pressure

  • Chapter
Contemporary Geriatric Medicine

Part of the book series: Contemporary Geriatric Medicine ((COGM,volume 2))

Abstract

Degenerative disease of the cardiovascular system remains the leading cause of morbidity and mortality in the elderly patient. Coronary artery disease accounts for approximately 40% of all deaths beyond age 55 years.1 An impressive reduction in fatalities due to ischemic heart disease has been seen in the United States during the past 15 years. This favorable statistic applied to both sexes, whites and nonwhites, and patients over 65 years as well. For white males aged 65 to 74 years, the death rate from ischemic heart disease has fallen from 2119 per 100,000 in 1968 to 1642 per 100,000 in 1977.1 A comparable reduction in the incidence of coronary attacks was not seen initially,2 but more recent data suggest that they too are decreasing in number.3 Reduction in mortality most likely results from a change in smoking habits, awareness of diet, better physical fitness, newer pharmacologic agents, and interventions such as coronary bypass. Other therapeutic advances, particularly in the prevention and treatment of rheumatic fever and the surgical treatment of cardiac disease, have increased the life-span of cardiac patients. Degenerative disease superimposed on preexisting valvular heart disease has resulted in an increasing population of elderly patients with “hybrid” heart disease. Appropriate therapy depends on early recognition of the underlying disease process and an understanding of its pathology. This task is made more difficult because the clinical history is often atypical or the physical signs are masked by the effects of aging on the cardiovascular system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Levy, R. I. and Feinleib, M., 1980, Risk Factors for coronary artery disease and their management in heart disease, in: Textbook of Cardiovascular Medicine ( E. Braunwald, ed.), W.B. Saunders Company, Philadelphia, London, and Toronto, pp. 1246–1278.

    Google Scholar 

  2. Kannel, W. B. and Thom, T. J., 1979, Implications of the recent decline in cardio-vascular mortality, Cardiovas. Med. 9: 983–997.

    Google Scholar 

  3. Gillum, R. F. and Folsum, A. R., 1984, Decline in coronary heart disease mortality. Old questions and new facts, Am. J. Med. 76: 1055–1065.

    PubMed  CAS  Google Scholar 

  4. Pomerance, A., 1976, Pathology of the myocardium and valves, in: Cardiology in Old Age ( F. I. Gaird, J. L. C. Dall, and R. D. Kennedy, eds.), Plenum Press, New York and London, pp. 11–55.

    Google Scholar 

  5. Lev, M., 1964, Anatomic basis for atrioventricular block, Am. J. Med. 37: 742–747.

    PubMed  CAS  Google Scholar 

  6. Dhingra, R. C., Amat-y-Leon, F., Pietras, R. J., Wyndham, C., Deedwania, P. C., Wu, D., Denes, P., and Rosen, K. M., 1977, Sites of conduction disease in aortic stenosis, Ann. Intern. Med. 87: 275–280.

    PubMed  CAS  Google Scholar 

  7. Bader, H., 1967, Dependence of wall stress in the human thoracic aorta on age and pressure, Circ. Res. 10: 354–361.

    Google Scholar 

  8. Gribbin, B., Pickering, T. G., Steight, P., and Peto, R., 1971, Effect of age and high blood pressure on baroreflex sensitivity in man, Circ. Res. 29: 421–431.

    Google Scholar 

  9. Strandell, T., 1976, Cardiac output in old age, in: Cardiology in Old Age ( F. I. Caird, J. L. C. Dall, and R. D. Kennedy, ed.), Plenum Press, New York and London, pp. 81–100.

    Google Scholar 

  10. Rodeheffer, R. J., Gerstenblith, G., Becker, L. C., Fleg, J. L., Weisfeldt, M. L., and Lakatta, E. G., 1984, Exercise cardiac output is maintained in healthy human subjects: Cardiac dilatation and increased stroke volume compensated for in diminished heart rate, Circulation 69: 203–212.

    PubMed  CAS  Google Scholar 

  11. Bethel, C. S. and Crow, E. W., 1963, Heart sounds in the aged, Am. J. Cardiol. 11: 763–767.

    PubMed  CAS  Google Scholar 

  12. Wong, M., Tei, C., and Shah, P. M., 1983, Degenerative calcific valvular disease and systolic murmurs in the elderly, J. Am. Geriatr. Soc. 31: 156–163.

    PubMed  CAS  Google Scholar 

  13. Ostenberger, L. E., Goldstein, S., Khaja, F., and Lakier, J. B., 1981, Functional mitral stenosis in patients with massive mitral annular calcification, Circulation 64: 472–476.

    Google Scholar 

  14. Kistler, J. P., Lees, R. S., Friedman, J., Pressin, M., Mohr, J. P., Roberson, G. S., and Ojemann, R. G., 1978, The bruit of carotid stenosis versus radiated vasal heart murmurs differentiation by phonoangiography, Circulation 57: 975–981.

    PubMed  CAS  Google Scholar 

  15. Fisch, C., 1981, Electrocardiogram in the aged: An independent marker of heart disease ? Am. J. Med. 70: 4–6.

    PubMed  CAS  Google Scholar 

  16. Chiang, B. N., Perlman, L. V., Ostrander, L. D., and Epstein, F. H., 1969, Relationship of premature systoles to coronary heart disease and sudden death in the Tecumseh Epidemiologic Study, Ann. Intern. Med. 70: 1159–1166.

    PubMed  CAS  Google Scholar 

  17. Camm, A. J., Evans, K. E., Ward, D. E., and Martin, A., 1980, The rhythm of the heart in active elderly subjects, Am. Heart J. 99: 598–603.

    PubMed  CAS  Google Scholar 

  18. Freisinger, G. C. and Smith, R. F., 1972, Correlation of electrocardiographic studies and artériographie findings with angina pectoris, Circulation 46: 1173–1184.

    Google Scholar 

  19. Ellestad, M. H., 1975, Predictive implications, in: Stress Testing Principles and Practice, F. A. Davis Company, Philadelphia, pp. 157–176.

    Google Scholar 

  20. Okada, R. D., Boucher, C. A., Strauss, H. W., and Pohost, G. M., 1980, Exercise radionuclide imaging approaches to coronary artery disease, Am. J. Cardiol. 46: 1188–1204.

    PubMed  CAS  Google Scholar 

  21. Port, S., Cobb, F. R., Coleman, R. E., and Jones, R. H., 1980, The effect of age in left ventricular function at rest and during exercise, N. Engl. J. Med. 303: 1131–1137.

    Google Scholar 

  22. Hakki, A. H., DePace, N. L., and Iskandrian, A. S., 1983, Effect of age on left ventricular function during exercise in patients with coronary artery disease, JACC 2: 645–651.

    PubMed  CAS  Google Scholar 

  23. Corbett, J. R., Dehmer, G. J., Lewis, S. E., Woodward, W., Henderson, E., Parkey, R. W., Blomqvist, C. G., and Willerson, J. T., 1981, The prognostic value of submaximal exercise testing with radionuclide ventriculography before hospital discharge in patients with recent myocardial infarction, Circulation 64: 535–544.

    PubMed  CAS  Google Scholar 

  24. Parkey, R. W., Bonté, F. J., Lewis, S. E., Buja, C. M., and Willerson, J. T., 1980, Acute myocardial infarct imaging using technetium-99m pyrophosphate, in: Nuclear Cardiology for Clinicians ( J. S. Soin and H. L. Brooks, eds.), Futura Publishing Company, Mt. Kisco, New York, pp. 133–150.

    Google Scholar 

  25. Falk, R. H., Lee, V. W., Rubinow, A., Hood, W. B., Jr., and Cohen, A. S, 1983, Sensitivity of technetium-99m pyrophosphate scintigraphy in diagnosing cardiac amyloidosis, Am. J. Cardiol. 51: 826–830.

    PubMed  CAS  Google Scholar 

  26. Gibson, T. C. and Heitzman, M. R., 1984, Diagnostic efficacy of 24-hour electrocardiographic monitoring for syncope, Am. J. Cardiol. 53: 1013 - 1017.

    PubMed  CAS  Google Scholar 

  27. Davis, K., Kennedy, J. W., Kemp, H. G., Jr., Judkins, M. P., Gosselin, A. J., and Killip, T., 1979, Complications of coronary angiography from the collaborative study of coronary artery surgery (CASS), Circulation 59: 1105–1112.

    PubMed  CAS  Google Scholar 

  28. Mason, J. W. and Winkle, R. A., 1980, Accuracy of the ventricular tachycardia induction study for predicting long-term efficacy of antiarrhythmic drugs, N. Engl. J. Med. 303: 1073–1077.

    PubMed  CAS  Google Scholar 

  29. Pathy, M. S., 1967, Clinical presentation of myocardial infarction in the elderly, Br. Heart J. 29: 190–199.

    PubMed  CAS  Google Scholar 

  30. Epstein, S. E., Kent, K. M., Goldstein, R. E., Borer, J. S., and Rosing, D. R., 1979, Strategy for evaluation and surgical treatment of the asymptomatic or mildly symp-tomatic patient with coronary artery disease, Am. J. Cardiol. 43: 1015–1025.

    Google Scholar 

  31. Hung, J., Goris, M. L., Nash, E., Kraemer, H. C., Debusk, R. F., Berger, W. E. III, and Lew, H., 1984, Comparative value of maximal treadmill testing, exercise thallium myocardial perfusion scintigraphy, and exercise radionuclide ventriculography for distinguishing high- and low-risk patients soon after acute myocardial infarction, Am. J. Cardiol. 53: 1221–1227.

    PubMed  CAS  Google Scholar 

  32. The Multicenter Postinfarction Research Group, 1983, Risk stratification and survival after myocardial infarction, N. Engl. J. Med. 309: 331–336.

    Google Scholar 

  33. Weiner, D. A., Ryan, T. J., McCabe, C. H., Chaitman, B. R., Sheffield, L. T., Ferguson, J. C., Fisher, L. D., and Tristani, F., 1984, Prognostic importance of a clinical profile and exercise test in medically treated patients with coronary artery disease, JACC 3: 772–779.

    PubMed  CAS  Google Scholar 

  34. Jones, R. H., McEwan, P., Newman, G. E., Port, S., Rerych, S. K., Scholz, P. M., Upton, M. T., Peter, C. A., Austin, E. H., Leong, K., Gibbons, R. J., Cobb, F. R., Coleman, R. E., and Sabiston, D. C. Jr., 1981, Accuracy of diagnosis of coronary artery disease by radionuclide measurement of left ventricular function during rest and exercise, Circulation 64: 586–601.

    PubMed  CAS  Google Scholar 

  35. Reichek, N., Priest, C., Zimrin, D., Chandler, T., and St. John Sutton, M., 1984, Antianginal effects of nitroglycerin patches, Am. J. Cardiol. 54: 1–13.

    Google Scholar 

  36. Olivari, M. T., Carlyle, P. F., Levine, T. B., and Cohn, J. N., 1983, Hemodynamic and hormonal response to transdermal nitroglycerin in normal subjects and in patients with congestive heart failure, JACC 2: 872–878.

    PubMed  CAS  Google Scholar 

  37. Beta Blocker Heart Attack Study Group, 1981, The beta blocker heart attack trial, JAMA 246: 2073–2074.

    Google Scholar 

  38. Norwegian Multicenter Study Group, 1981, Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction, N. Engl. J. Med. 304: 801–807.

    Google Scholar 

  39. Frishman, W. H., 1981, Beta adrenoceptor antagonists: New drugs and new indications, N. Engl. J. Med. 305: 500–506.

    PubMed  CAS  Google Scholar 

  40. Ahumada, G. G., 1984, Identification of patients who do not require beta antagonists after myocardial infarction, Am. J. Med. 76: 900–904.

    PubMed  CAS  Google Scholar 

  41. Antman, E. M., Stone, P. H., Muller, J. E., and Braunwald, E., 1980, Calcium channel blocking agents in the treatment of cardiovascular disorders. Part I: Basic and clinical electrophysiologic effects, Ann. Intern. Med. 93: 875–885.

    PubMed  CAS  Google Scholar 

  42. Stone, P. H., Antman, E. M., Muller, J. E., and Braunwald, E., 1980, Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications, Ann. Intern. Med. 93: 866–904.

    Google Scholar 

  43. Kawai, C., Konishi, T., Maysuyama, E., and Okazaki, H., 1981, Comparative effects of three calcium antagonists—diltiazem, verapamil, nifedipine—on sinoatrial and atrioventricular nodes, Circulation 63: 1035–1042.

    PubMed  CAS  Google Scholar 

  44. Proceedings of the Workshop on Platelet Active Drugs in the Secondary Prevention of Cardiovascular Events, 1980, Circulation 62 (Suppl. V): 1–135.

    Google Scholar 

  45. Cines, D. B., Kaywin, P., Bina, M., Tomaski, A., and Schrieber, A. D., 1980, Heparin associated thrombocytopenia, N. Engl. J. Med. 303: 788–795.

    PubMed  CAS  Google Scholar 

  46. Miller D. H. and Borer, J. S., 1982, Exercise testing early after myocardial infarction, Am. J. Med. 72: 427–438.

    PubMed  CAS  Google Scholar 

  47. Jolly, W. W., Isch, J. H., and Schumacker, H. R., 1981, Cardiac surgery in the elderly, in: Cardiovascular Clinics, Volume 12, Number 2 ( R. J. Noble, D. A. Rothbaum, eds.), F.A. Davis Company, Philadelphia, pp. 195–210.

    Google Scholar 

  48. Rahimtoola, S. H., Grunkemeier, G., Tepley, J., Lambert, L., Thomas, D. R., Yuen-Fure, S., and Starr, A., 1981, Changes in coronary bypass surgery leading to improved survival, JAMA 246: 1912–1219.

    PubMed  CAS  Google Scholar 

  49. Kennedy, J. W., Kaiser, G. C., Fischer, L. D., Fritz, J. K., Myers, W., Mudd, J. G., and Ryan, T. J., 1981, Clinical and angiographic predictors of operative mortality from collaborative study in coronary artery (CASS) Circulation 63: 793–802.

    PubMed  CAS  Google Scholar 

  50. Pomerance, A., 1965, Pathology of the heart with and without cardiac failure in the aged, Br. Heart J. 27: 697–709.

    PubMed  CAS  Google Scholar 

  51. Schlatmann, T. J. M. and Becker, A. E., 1977, Histologic changes in the normal aging aorta: Implications for dissecting aortic aneurysm, Am. J. Cardiol. 39: 13–20.

    PubMed  CAS  Google Scholar 

  52. Finegan, R. E., Gianelly, R. E., and Harrison, D. C., 1969, Aortic stenosis in the elderly. Relevance of age to diagnosis and treatment, N. Engl. J. Med. 281: 1261–1264.

    PubMed  CAS  Google Scholar 

  53. Glancy, L., Freed, T. A., O’Brien, K. P., and Epstein, S., 1969, Calcium in the aortic valve-roentgenographic and hemodynamic correlations in 148 patients, Ann. Intern. Med. 71: 246–250.

    Google Scholar 

  54. Wann, L. S., and Dillon, J. C., 1978, Echocardiography of the aortic valve, in: Handbook of Clinical Ultrasound ( M. DeVlieger, ed.), John Wiley and Sons, New York, pp. 453–563.

    Google Scholar 

  55. Wagner, S. and Selzer, A., 1980, Natural history of unoperated aortic stenosis: Hemodynamic progression, Am. J. Cardiol. 45: 440 (abstr.).

    Google Scholar 

  56. Tresch, D. D., Siegel, R., Keelan, M. H. Jr., Gross, C. M., and Brooks, H. L., 1979, Mitral valve prolapse in the elderly, J. Am. Geriatr. Soc. 27: 421–424.

    PubMed  CAS  Google Scholar 

  57. Kolibash, A. J., Bush, C. A., Fontana, M. B., Ryan, J. M., Kicman, J., and Wooley, C. F., 1983, Mitral valve prolapse syndrome: Analysis of 62 patients aged 60 years and older, Am. J. Cardiol. 52: 534–539.

    PubMed  CAS  Google Scholar 

  58. Cooper, E. S., Cooper, J. W., and Schnabel, T. G., 1966, Pitfalls in the diagnosis of bacterial endocarditis, Arch. Intern. Med. 118: 55–61.

    CAS  Google Scholar 

  59. St. John Sutton, M. G., Tajik, A. J., and McGoon, D. C., 1981, Atrial septal defect in patients ages 60 years or older: Operative results and long-term postoperative follow-up, Circulation 64: 402–409.

    Google Scholar 

  60. Dhingra, R. C., Wyndham, C., Amat-y-Leon, F., Denes, P., Wu, D., Sridhar, $., Bustin, A. G., and Rosen, K. M., 1979, Incidence and site of atrioventricular block in patients with chronic bifascicular block, Circulation 59: 238–246.

    CAS  Google Scholar 

  61. Rodstein, M., Wolloch, L., and Luster, Z., 1979, The natural history of intraventricular conduction disturbances in the aged: An analysis of the magnitude of risk of developing second and third degree heart block with clinical pathological correlations, Am. J. Med. Sci. 277: 179–188.

    PubMed  CAS  Google Scholar 

  62. McAnulty, J. H. and Rahimtoola, S. H., 1981, Chronic bundle branch block—Clinical significance and management, JAMA 246: 2202–2204.

    PubMed  CAS  Google Scholar 

  63. Ruberman, W., Weinblatt, E., Goldberg, J. D., Frank, C. W., and Shapiro, S., 1977, Ventricular premature beats and mortality after myocardial infarction, N. Engl. J. Med. 297: 750–757.

    PubMed  CAS  Google Scholar 

  64. DiMarco, J. P., Garan, H., Harthorne, J. W., and Ruskin, J. N., 1981, Intracardiac electrophysiologic techniques in recurrent syncope of unknown cause, Ann. Intern. Med. 95: 542–548.

    Google Scholar 

  65. Lovett, J. L., Sandok, B. A., Giuliani, E. R., and Nasser, F. N., 1981, Two-dimensional echocardiography in patients with focal cerebral ischemia. Ann. Intern. Med. 95: 1–4.

    PubMed  CAS  Google Scholar 

  66. Dodek, A., 1979, The serum digoxin test: A clinical perspective, Cardiol. Digest 14: 19–24.

    Google Scholar 

  67. Mulrow, C. D., Feussner, J. R., and Velez, R., 1984, Reevaluation of digitalis: Efficacy, new light on an old leaf, Ann. Intern. Med. 101: 113–117.

    PubMed  CAS  Google Scholar 

  68. Cohn, J. N. and Franciosa, J. A., 1977, Vasodilator therapy in cardiac failure, N. Engl. J. Med. 297:27–31, 254–258.

    Google Scholar 

  69. Weber, K. T., 1982, New hope for the failing heart, Am. J. Med. 72: 665–670.

    PubMed  CAS  Google Scholar 

  70. Arkins, R., Smessaert, A. A., and Hicks, R. G., 1964, Mortality and morbidity in surgical patients with coronary artery disease, JAMA 190: 485–488.

    PubMed  CAS  Google Scholar 

  71. Goldman, L., Caldera, D. L., Southwick, F. S., Nussbaum, S. R., Murray, B., O’Malley, T. A., Goroll, A. H., Caplan, C. H., Nolan, J., Burke, D. S., Krogstad, D., Carabello, A. C., and Slater, E. E., 1978, Cardiac risk factors and complications in noncardiac surgery, Medicine 57: 357–370.

    PubMed  CAS  Google Scholar 

  72. Harken, D. E., 1977, Malnutrition: A poorly understood surgical risk factor in aged cardiac patients, Geriatriçs 32: 83–85.

    PubMed  CAS  Google Scholar 

  73. Skinner, J. F. and Pearce, M. L., 1964, Surgical risk in the cardiac patient, J. Chronic Dis. 17: 57–72.

    PubMed  CAS  Google Scholar 

  74. Tarhan, S., Moffitt, E. A., Taylor, W. F., and Giuliani, E. R., 1972, Myocardial infarction after general anesthesia, JAMA 220: 1451–1454.

    PubMed  CAS  Google Scholar 

  75. Bonchek, L. I., Olinger, G. N., Keelan, M. H. Jr., Tresch, D. D., and Siegel, R., 1977, Management of sudden coronary death, Ann. Thoracic Surg. 24: 337–345.

    CAS  Google Scholar 

  76. American Heart Association Committee Report (E. L. Kaplan, Chairman), 1977, Prevention of bacterial endocarditis, Circulation 56 (1): 139A–143A.

    Google Scholar 

  77. Izzo, J. L., 1982, Hypertension in the elderly: A pathophysiologic approach to therapy, J. Am. Geriatr. Soc. 30: 352–359.

    Google Scholar 

  78. Chobanian, A. V., 1983, Pathophysiologic considerations in the treatment of the elderly hypertensive patient, Am. J. Cardiol. 52: 49D–53D.

    PubMed  CAS  Google Scholar 

  79. Garvas, H. and Garvas, I., 1983, Hypertension in the Elderly, John Wright, PSG Inc. Boston.

    Google Scholar 

  80. Franklin, S. S., 1983, Geriatric hypertension, Med. Clin. North Am. 67: 395–417.

    CAS  Google Scholar 

  81. Young, J. B., Rowe, J. W., Pallotta, J. A., Sparrow, D., and Landsberg, L., 1980, Enhanced plasma norepinephrine response to upright posture and oral glucose administration in elderly human subjects, Metabolism 29: 532–539.

    PubMed  CAS  Google Scholar 

  82. Pfeifer, M. A., Weinberg, C. R., Cook, D., Best, J., Reenan, A., and Halter, J. B., 1983, Differential changes of autonomic nervous system function with age in man, Am. J. Med. 75: 249–258.

    PubMed  CAS  Google Scholar 

  83. Vestal, R., Wood, A. J. J., and Shand, D. G., 1979, Reduced beta-adrenoreceptor sensitivity in the elderly, Clin. Pharmacol. Ther. 26: 181–186.

    CAS  Google Scholar 

  84. Tobian, L., 1979, Dietary salt (sodium) and hypertension, Am. J. Clin. Nutr. 32 (Suppl. 12): 2659–2663.

    PubMed  CAS  Google Scholar 

  85. Tobian, L., 1979, The relationship of salt to hypertension, Am. J. Clin. Nutr. 32(Suppl. 12)2739–2748.

    PubMed  CAS  Google Scholar 

  86. Weiffenbach, J. M., Baum, B. J., and Burghauser, R., 1982, Taste thresholds: Quality specific variation with human aging, J. Gerontol. 37: 372–377.

    PubMed  CAS  Google Scholar 

  87. Laragh, J. H. and Pecker, M. S., 1983, Dietary Sodium and Essential Hypertension: Some myths, hopes and truths, Ann, Intern. Med. (part 2) 98: 735–743.

    CAS  Google Scholar 

  88. Miall, W. E. and Lovell, H. G., 1967, Relation between change of blood pressure and age, Br. Med. J. 2: 660–664.

    PubMed  CAS  Google Scholar 

  89. Kannel, W. B., 1976, Blood pressure and the development of cardiovascular disease in the aged, in: Cardiology in Old Age ( F. I. Caird, J. L. C. Dall, and R. D. Kennedy, eds.), Plenum Press, New York and London, pp. 143–175.

    Google Scholar 

  90. National Health Survey, 1975, Blood Pressure of Persons 18-74 Years in United States from 1971–1972, National Center for Health Statistics, Rockville, Maryland.

    Google Scholar 

  91. Sinnet, P. F. and Whyte, H. M., 1973, Epidemiological studies in a total highland population-Tukisenta, New Guinea: Cardiovascular disease and relevant clinical, electrocardiographic, radiological, and biochemical findings, J. Chron. Dis. 26: 265–290.

    Google Scholar 

  92. Truswell, A. S., Kennelly, B. M., Hansen, J. D. L., and Lu, R. B., 1972, Blood pressures of Kury bushmen in northern Botswanna, Am. Heart J. 84: 5–12.

    PubMed  CAS  Google Scholar 

  93. Kaplan, N. M., 1983, Hypertension: Prevalence, risks, and effect of therapy, Ann. Intern. Med. 98 (Part 2): 705–709.

    PubMed  CAS  Google Scholar 

  94. Dyer, A. R., Stamler, J., Shekelle, R. B., Schoenberger, J., and Farinaro, E., 1977, Hypertension in the elderly, Med. Clin. North Am. 61: 513–529.

    CAS  Google Scholar 

  95. Kennedy, R. D., 1976, High blood pressure and its management, in: Cardiology in Old Age ( F. I. Caird, J. L. C. Dall, and R. D. Kennedy, eds.), Plenum Press, New York and London, pp. 177–190.

    Google Scholar 

  96. Spence, J. D. Sibbald, W. J., and Cape, R. D., 1978, Pseudohypertension in the elderly, Clin. Sci. Mol. Med. 59: 399s–402s.

    Google Scholar 

  97. Vardan, S., Mookherjee, S., Warner, E., and Smulyan, H., 1983, Systolic hypertension: Direct and indirect BP measurements, Arch. Intern. Med. 143: 935–938.

    CAS  Google Scholar 

  98. O’Callaghan, W. G., Fitzgerald, D. J., O’Malley, K., and O’Brien, E., 1983, Accuracy of Indirect Blood Pressure Measurement in the Elderly, Br. Med. J. 286: 1545–1546.

    Google Scholar 

  99. Caird, R. I., Andrews, G. R., and Kennedy, R. D., 1973, Effect of posture on blood pressure in the elderly, Br. Heart f. 35: 527–530.

    CAS  Google Scholar 

  100. Dollery, C., Fagard, R., Forette, F., Hellemans, J., Lund-Johnsen, P., Mutsers, A., and Tuomilehto, J., 1978, Glucose intolerance during diuretic therapy: Results from the European Working Party on High Blood Pressure in the Elderly trial, Lancet 1: 681–683.

    PubMed  Google Scholar 

  101. Whitehouse, W. M., Kazmers, A., Zelenviu, G., Erlandson, E., Cronenwett, J., Lindenaver, S., and Stanley, J. C., 1981, Chronic total renal artery occlusion-Effects of treatment on secondary hypertension and renal function, Surgery 89: 753–763.

    PubMed  Google Scholar 

  102. Grim, E. E., Luft, F. C., Yune, H. Y., Klatte, E., Weinberger, M., 1981, Percutaneous transluminal dilatation in the treatment of renal vascular hypertension, Ann. Intern. Med. 95: 439–442.

    PubMed  CAS  Google Scholar 

  103. Sos, T. A. Pickering, T. G., Sniderman, K., Saddekni, S., Case, D. B., Silane, M. F., Vaughan, E. D., and Laragh, J. H., 1983, Percentaneous transluminal angioplasty in renovascular hypertension due to atheroma or fibromuscular dysplasia, N. Engl. J. Med. 309: 274–279.

    Google Scholar 

  104. Brown, J., 1982, Digital subtraction arteriography of the abdomen with emphasis on renal vasculature, in: Digital Subtraction Arteriography and Application of Computerized Fluoroscopy ( G. Mistretta, A. Crummy, C. Strother, and J. Sackett, eds.), Year Book Medical Publishers, Inc., Chicago, pp. 69–73.

    Google Scholar 

  105. Madias, N. E., Kwon, O. J., and Millan, V. G., 1982, Percutaneous transluminal angioplasty: A potentially effective treatment for preservation of renal function, Arch. Intern. Med. 142: 693–697.

    CAS  Google Scholar 

  106. Messerli, F. H., Frohlich, E. D., Suarez, D. H., Reisin, E., Dreslinski, G., Dunn, F., and Cole, F., 1981, Borderline hypertension: Relationship between age, hemodynamics, and circulating calectrolamines, Circulation 64: 760–764.

    PubMed  CAS  Google Scholar 

  107. Messerli, F. H., Ventura, H. O., Glade, L. B., Sundgaard-Riise, K., Dunn, F. G., and Frohlich, E. D., 1983, Essential hypertension in the elderly: Hemodynamics, intravascular volume, plasma renin activity, and circulating catecholamine levels, Lancet (8357): 983–986.

    Google Scholar 

  108. Vardan, S., Mookherjee, S., Warner, R., and Smulyan, H., 1983, Systolic hypertension in the elderly, JAMA 250: 2807–2813.

    PubMed  CAS  Google Scholar 

  109. Lake, C. R., Ziegler, M. G., Coleman, M. D., and Kopin, I. J., 1977, Age-adjusted plasma norepinephrine levels are similar in normotensive and hypertensive subjects, N. Engl. J. Med. 296: 208–209.

    PubMed  CAS  Google Scholar 

  110. Mandai, T., Ogihara, T., Hata, T., Okada, T., Ogasahara, S., Nikami, H., Nakamaru, M., and Kumahara, Y., 1980, Urinary catecholamine response to glucagon in young and elderly patients with essential hypertension, J. Am. Geriatr. Soc. 28: 462–465.

    PubMed  CAS  Google Scholar 

  111. Takeda, R., Morimoto, S., Uchida, K., Miyamori, I., and Hashiba, T., 1980, Effect of age on plasma aldosterone response to exogenous angiotensin II in normotensive subjects, Acta Endocrinol. 94: 552–558.

    PubMed  CAS  Google Scholar 

  112. Morimoto, S., Uchida, K., Miyamoto, M., Kigoshi, T., Morise, T., Takimoto, H., and Takeda, R., 1981, Plasma aldosterone response to angiotensin II in sodium-restricted elderly subjects with essential hypertension, J. Am. Geriatr. Soc. 29: 302–307.

    PubMed  CAS  Google Scholar 

  113. Ogihara, T., Hata, T., Maruyama, A., Mikami, M., Nakamaru, M., Mandai, T., and Kumahara, Y., 1979, Studies on the renin-angiotensin-aldosterone system in elderly hypertensive patients with angiotensin II antagonist, Clin. Sci. 57: 461–463.

    CAS  Google Scholar 

  114. Naka, T., Ogihara, T., Hata, T., Maruyama, A., Mikami, H., Nakamaru, M., Gotoh, S., Masuo, K., Ohde, H., Iwanaga, K., and Kumahara, T., 1981, The effect of aging on urinary kallikrein excretion in normotensive subjects and in patients with essential hypertension, J. Clin. Endocrinol. Metab. 52: 1023–1026.

    PubMed  CAS  Google Scholar 

  115. Koch-Weser, J., 1979, Treatment of hypertension in the elderly, in: Drugs and the Elderly ( J. Crooks and I. H. Stevenson, eds.), University Park Press, Baltimore, pp. 247–262.

    Google Scholar 

  116. Gifford, R., 1982, Isolated systolic hypertension in the elderly: Some controversial issues, JAMA 247: 781–785.

    PubMed  Google Scholar 

  117. Chobanian, A. V., 1981, Therapeutic decision making in systolic hypertension, Geriatrics 36 (3): 36–41.

    PubMed  CAS  Google Scholar 

  118. The Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure, 1984, The 1984 Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure, Arch. Intern. Med., 144: 1045–1057.

    Google Scholar 

  119. Gray, D. R., Weber, M. A., Drayer, J., 1983, Effects of low dose antihypertensive therapy in elderly patients with predominant systolic hypertension, J. Gerontol. 38: 302–306.

    PubMed  CAS  Google Scholar 

  120. Five year findings of the Hypertension Detection and Follow-up Program. I. Reduction in mortality of persons with high blood pressure including mild hypertension, 1979, JAMA 242: 2562–2571.

    Google Scholar 

  121. Five year findings of the Hypertension Detection and Follow-up Program. II. Mortality by race, sex, and age, 1979, JAMA 242: 2572–2577.

    Google Scholar 

  122. Libow, L. and Butler, R. N., 1981, Treating mild diastolic hypertension in the elderly: Uncertain benefits and possible dangers, Geriatrics 36 (11): 55–62.

    PubMed  CAS  Google Scholar 

  123. Amery, A. and DeSchaepdryver, A. 1973, European Working Party on High Blood Pressure in the Elderly (EWPHE). Organization of double-blind multi-centre trial on antihypertensive therapy in elderly patients, Clin. Sci. Mol. Med. 45: 71s–73s.

    Google Scholar 

  124. Kuramoto, K., Matsushita, S., Kuwajima, I., and Mvrakami, M., 1981, Prospective study on the treatment of mild hypertension in the aged, Jap. Heart J. 22: 75–85.

    CAS  Google Scholar 

  125. Toth, P. J. and Horwitz, R. I., 1983, Conflicting Clinical Trials and the Uncertainty of Treating Mild Hypertension, Am. J. Med. 75: 482–488.

    PubMed  CAS  Google Scholar 

  126. Ram, C. V., 1984, Should mild hypertension be treated?, Med. Clin. North Am. 68: 469–476.

    CAS  Google Scholar 

  127. Grimm, R. H., 1984, Should mild hypertension be treated?, Med. Clin. North Am. 68: 477–490.

    Google Scholar 

  128. Multiple Risk Factor Intervention Trial Research Group, 1982, Multiple Risk Factor Intervention Trial, JAMA 248: 1465–1477.

    Google Scholar 

  129. Parijs, J., Joossens, J. V., VanderLinden, L., Verstreken, G., and Amery, A., 1973, Moderate sodium restriction and diuretics in the treatment of hypertension, Am. Heart J. 85: 22–34.

    PubMed  CAS  Google Scholar 

  130. MacGregor, G. A., Markanov, W. D., Best, F. E., Elder, D. M., Cam, J. M., Sagnella, G. A., and Squires, M., 1982, Double-blind randomized cross over trial of moderate sodium restriction in essential hypertension, Lancet 1: 351–355.

    PubMed  CAS  Google Scholar 

  131. Langford, H. G., 1983, Potassium in hypertension, Postgrad Med. 73: 227–233.

    PubMed  CAS  Google Scholar 

  132. McCarron, D. A., Morris, C. D., Henry, H. J., and Stanton, J. L., 1984, Blood pressure and nutrient intake in the United States, Science 224: 1392–1398.

    PubMed  CAS  Google Scholar 

  133. Reisin, E., Abel, R., Modan, M., Silverberg, D., Eliahou, H., and Modan, B., 1978, Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients, N. Engl. J. Med. 298: 1–6.

    PubMed  CAS  Google Scholar 

  134. Morisky, D. E., Levine, D. M., Green, L. W., and Smith, C. R., 1982, Health education program effects on the management of hypertension in the elderly, Arch. Intern. Med. 142: 1835–1838.

    CAS  Google Scholar 

  135. Navarro, R., O’Brien, D. L., Nuffort, P., and Spencer, D. L., 1982, Diuretic induced hypokalemia in the elderly, J. Fam. Pract. 14: 685–689.

    PubMed  CAS  Google Scholar 

  136. Ouslander, J. G., 1981, Urinary incontinence in the elderly, West. J. Med. 135: 482–491.

    PubMed  CAS  Google Scholar 

  137. Thanopavarn, C., Golub, M. S. and Sambhi, M. P., 1983, Clonidine in the elderly hypertensive, Chest 83 (Suppl.): 410s–411s.

    Google Scholar 

  138. Messerli, F. H., Dreslinski, G. R., Husserl, R. E., Svarez, D., MacPhee, A., and Fröhlich, E., 1981, Antiadrenergic therapy: Special aspects in hypertension in the elderly, Hypertension 3 (Suppl. II): 226–229.

    Google Scholar 

  139. Sotaniemi, E. A., Hukkanen, O. T., Akokas, J. I., Pelkonen, R. O., and Ahlqvist, J., 1977, Hepatic injury and drug metabolism in patients with alpha-methylodopa induced liver damage, Eur. J. Clin. Pharmacol. 12: 429–435.

    PubMed  CAS  Google Scholar 

  140. Castelden, C. M. and George, C. F., 1979, The effect of age on the hepatic clearance of propranolol, Br. J. Clin. Pharmacol. 7: 49–54.

    Google Scholar 

  141. Veterans Administration Cooperative Study Group on Antihypertensive Agents, 1967, Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg, JAMA 202: 1028–1034.

    Google Scholar 

  142. Luxemberg, J. and Feigenbaum, L. F., 1983, The use of reserpine for elderly hypertensive patients, J. Am. Geriatr. Soc. 31: 556–559.

    Google Scholar 

  143. Applegate, W. B., Carper, E. R., Kahn, S., Westbrook, L., Linton, M., and Baker, M., 1983, (abstract) Retrospective analysis of the long term efficacy of reserpine vs Aldomet in elderly black hypertensive patients, J. Am. Geriatr. Soc. 32(Suppl.):s6.

    Google Scholar 

  144. Vidt, D. G., Bravo, E. L., and Fouad, F. M., 1982. Drug therapy—Captopril. N. Engl. J. Med. 306: 214–219.

    PubMed  CAS  Google Scholar 

  145. Kaplan, N. M., 1984, New drugs for treatment of hypertension, Resident Staff Phy-sician, 30 (1): 29–34.

    Google Scholar 

  146. Anonymous, 1983, Bumetanide—A new “loop” diuretic, Med. Letter 25: 61–63.

    Google Scholar 

  147. Anonymous, 1984, Indapamide—A new antihypertensive agent and diuretic, Med. Letter 26: 17–18.

    Google Scholar 

  148. Anonymous, 1983, Guanadril—A new antihypertensive drug, Med. Letter 25: 95–96.

    Google Scholar 

  149. Anonymous, 1983, Guanabenz—A new antihypertensive drug, Med. Letter 25: 11–12.

    Google Scholar 

  150. Prosnitz, E. H., 1982, Therapy of hypertension, in: Drug Therapy for the Elderly ( K. Conrad and R. Bressler, eds.), C. V. Mosby Company, St. Louis.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Publishing Corporation

About this chapter

Cite this chapter

Duthie, E.H., Keelan, M.H. (1986). Geriatric Cardiology and Blood Pressure. In: Gambert, S.R. (eds) Contemporary Geriatric Medicine. Contemporary Geriatric Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5000-2_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5000-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5002-6

  • Online ISBN: 978-1-4684-5000-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics