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Transcription of Cloned Eukaryotic Ribosomal RNA Genes

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Genetic Engineering: Principles and Methods

Part of the book series: Genetic Engineering: Principles and Methods ((GEPM,volume 7))

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Abstract

A typical eukaryotic cell devotes about half of its transcriptional capacity to the synthesis of only one kind of RNA — this is the 40 to 47S ribosomal RNA (rRNA), precursor to the mature 18S, 28S and 5.8S RNAs of the ribosome. The transcription of ribosomal DNA (rDNA) is both very efficient and highly regulated, reflecting the cellular need to produce more than a million new ribosomes per generation which are required for protein synthesis.

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Authors and Affiliations

  1. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21210, USA

    B. Sollner-Webb, J. Tower, V. Culotta & J. Windle

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  1. B. Sollner-Webb
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  2. J. Tower
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  3. V. Culotta
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Editors and Affiliations

  1. Brookhaven National Laboratory, Upton, New York, USA

    Jane K. Setlow

  2. Council for Research Planning in Biological Sciences, Inc., Washington, D.C., USA

    Alexander Hollaender

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Sollner-Webb, B., Tower, J., Culotta, V., Windle, J. (1985). Transcription of Cloned Eukaryotic Ribosomal RNA Genes. In: Setlow, J.K., Hollaender, A. (eds) Genetic Engineering: Principles and Methods. Genetic Engineering: Principles and Methods, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4973-0_14

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