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Biochemical and Genetic Analysis of Adenovirus DNA Replication In Vitro

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Genetic Engineering: Principles and Methods

Part of the book series: Genetic Engineering: Principles and Methods ((GEPM,volume 7))

Abstract

The replication of DNA is a fundamental process in cell metabolism which is controlled throughout the cell growth cycle both in its timing and extent. The initiation of a replicative phase in eukaryotic cells is subject to many environmental influences which we do not understand, but prerequisite to understanding the control of DNA replication is knowledge of the way DNA replicates. Elegant studies with bacteria and their phages have established basic principles about the mechanism of DNA replication and the enzymes that complete the task and these studies have relied heavily upon the use of genetics as a method of analysis. In higher eukaryotic cells, the lack of simple genetics has hampered progress toward elucidation of the mechanism of DNA synthesis, particularly how DNA replication gets under way and what immediate events control this process. Many investigators have turned to the replication of DNA viruses in mammalian cells in an attempt to circumvent some of these problems, particularly because these viruses often allow genetic analysis to be employed.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA

    Bruce W. Stillman

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  1. Bruce W. Stillman
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  1. Brookhaven National Laboratory, Upton, New York, USA

    Jane K. Setlow

  2. Council for Research Planning in Biological Sciences, Inc., Washington, D.C., USA

    Alexander Hollaender

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© 1985 Plenum Press, New York

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Stillman, B.W. (1985). Biochemical and Genetic Analysis of Adenovirus DNA Replication In Vitro . In: Setlow, J.K., Hollaender, A. (eds) Genetic Engineering: Principles and Methods. Genetic Engineering: Principles and Methods, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4973-0_1

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