Abstract
Much of this conference has been concerned with issues created by the “New Genetics,” however that be defined. We have turned in this closing session to a much less spectacular issue, but an issue that, in the aggregate, will probably impact, directly or indirectly, on just as many people as any of the other issues covered at this meeting. I refer to the question of the genetic implications of a wide variety of potentially mutagenic exposures in the workplace and the environment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Engle, R. L., and White, M. K., Fiscal Implementations of a Mil/Kilowatt Hour Waste Management Fee ,Battelle Pacific Northwest Laboratory (1982), Document 4513.
Land, C. E., Estimating cancer risks from low doses of ionizing radiation, Science 209:1197–1203 (1980).
Denniston, C., Low level radiation and genetic risk estimation in man, Ann. Rev. Genet. 16:329–55 (1982).
Neel, J. V., Frequency of spontaneous and induced point mutations in higher eukaryotes, J. Hexed. 74:2–15 (1983).
Kohn, H. I., Radiation genetics: The mouse’s view. Rad. Res. 94:1–9 (1983).
Lyon, M. F., Problems in extrapolation of animal data to humans, in Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk (F. J. deSerres and W. Sheridan, eds.), Plenum Press, New York (1983), 289–305.
Schull, W. J., Otake, M., and Neel, J. V. A reappraisal of the genetic effects of the atomic bombs: Summary of a thirty-four year study, Science 213:1220–7 (1981).
Neel, J. V., Nishimoto, Y., Goriki, K., Satoh, C., Fujita, M., and Yoshimoto, Y., Epidemiological studies of germ cell mutation in human populations, with particular reference to groups with unusual chemical exposures, in Methods for Estimating Risk of Chemical Injury: Human and Non-human Biota and Ecosystems (V. B. Vouk, G. L. Butler, D. G. Hoel, and D. B. Peakall, eds.), Wiley & Sons, Sussex (1985), 327–342.
Neel, J. V., Rosenblum, B. B., Sing, C. F., Skolnick, M. M., Hanash, S. M., and Sternberg, S., Adapting two-dimensional gel electrophoresis to the study of human germ-line mutation rates, in Methods and Applications of Two-Dimensional Gel Electrophoresis of Proteins (J. E. Celis, ed.), Academic Press, New York (1984), 259–306.
Skolnick, M. M., Sternberg, S. R., and Neel, J. V., Computer programs for adapting two-dimensional gels to the study of mutation, Clin. Chem. 28:969–78 (1982).
Skolnick, M. M., An approach to completely automatic comparison of two-dimensional electrophoresis gels, Clin. Chem. 28:979–86 (1982).
Bond, V. P., The medical effects of radiation, in Proceedings, Thirteenth Annual Convention, National Association Claimant’s Counsel of America ,W. H. Anderson, Cincinnati, (1959), 117–28.
Bond, V. P., The cancer risk attributable to radiation exposure: Some practical problems, Hlth. Phys. 40:108–11 (1981).
Bond, V. P., Statement. Hearings on Radiation Exposure Compensation Act of 1981 (S. 1483). GPO, Washington (1982), 242–257.
Oftedal, P., Kunt, M., and Torlief, H., On the probability of radiation being the cause of cancer, Br J Radiol. 41:711–2(1968).
Kolata, G. B., Love Canal: False alarm caused by botched study, Science 208:1239–42 (1980).
Picianno, D., Comment on Love Canal, Science 209:754–5 (1980).
Yamasaki, E., and Ames, B. N., Concentration of mutagens from urine by absorption with the nonpolar resin XAD-2: Cigarette smokers have mutagenic urine. Proc. Nat. Acad. Sci. USA 74:3555–9 (1977).
Hopkin, J. M., and Evans, H. J., Cigarette smoke condensates damaged DNA in human lymphocytes, Nature 279:241–2 (1979).
Obe, G., and Herha, J., Chromosomal aberrations in heavy smokers, Hum. Genet. 41:259–63 (1978).
Lambert, B., Linblad, A., Nordenskjold, M., and Werelius, B., Increased frequency of sister chromatid exchanges in cigarette smokers, Hereditas 88:147–9 (1978).
Hopkin, J. M, and Evans, H. J., Cigarette smoke-induced DNA damage and lung cancer risks, Nature 283:388–90 (1980).
Livingston, G. K., Cannon, L. A., Bishop, D. T., Johnson, P., and Fineman, R. M., Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status, Cancer Genet. Cytogenet. 9:289–98 (1983).
Hollander, D. H., Tockman, M. S., Liang, Y. W., Borgaonkar, D. S., and Frost, J. K., Sister chromatic exchanges in the peripheral blood of cigarette smokers and in lung cancer patients; and the effects of chemotherapy, Hum. Genet. 44:165–171 (1978).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Aubrey Milunsky and George J. Annas
About this chapter
Cite this chapter
Neel, J.V. (1985). How Can We Best Evaluate, and Compensate for, Genetic Hazards in the Environment and Workplace. In: Milunsky, A., Annas, G.J. (eds) Genetics and the Law III. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4952-5_33
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4952-5_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4954-9
Online ISBN: 978-1-4684-4952-5
eBook Packages: Springer Book Archive