Abstract
Prenatal genetic diagnosis provides reassurance to couples at risk that they may selectively have offspring without serious mental retardation and/or chronic or serious-to-fatal disease.1 More babies are born because of the availability of prenatal diagnosis compared to the number of pregnancies terminated. Prenatal diagnosis is a life-giving, not a life-taking, technology. Amniocentesis for genetic diagnosis has been documented as a very low-risk procedure for almost a decade,2 and less than 3% of women undergoing amniocentesis for genetic risks need to face a decision to terminate a pregnancy.1 Abortions as a consequence of prenatal diagnosis account for a minute fraction of 1 % of all abortions performed.
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References
Milunsky, A. (ed.), Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment. Plenum Press, New York, 1979.
The NICHD National Registry for Amniocentesis Study Group, Midtrimester amniocentesis for prenatal diagnosis: Safety and accuracy, /. Am. Med. Assoc. 236:1471 (1976).
Shaw, M., To be or not to be? That is the question, Am. /. Hum. Genet. 36:1 (1984).
Milunsky, A., and Annas, G. J. (eds.), Genetics and the Law I ,Plenum Press, New York (1976).
Milunsky, A., and Annas, G. J. (eds.), Genetics and the Law II ,Plenum Press, New York (1980).
Turpin v. Sortini ,643 P. 2d 954 (Cal., 1982).
Harbeson v. Parke-Davis ,656 P.2d 483 (Wash., 1983).
Campbell, S., Diagnosis of fetal abnormalities by ultrasound, in Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment (A. Milunsky, ed.), Plenum Press, New York (1979).
National Institutes of Health Consensus Development Conference, consensus statement, Diagnostic ultrasound in pregnancy, U.S. Government Printing Office, Washington, DC (1984).
Mahoney, M. J., and Hobbins, J. C., Fetoscopy and fetal blood sampling, in Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment (A. Milunsky, ed.), Plenum Press, New York (1979).
Mass General Laws chap 112, 12J.
Hahnemann, N., and Mohr, J., Antenatal fetal diagnosis in genetic disease, Bull. Eur. Soc, Hum. Genet. 3:47 (1969).
Tietung Hospital Department of Obstetrics and Gynecology, Fetal sex prediction by sex chromatin of chorionic villi cells during early pregnancy, Chinese Med. J. 1:117 (1975).
Rhine, S. A., and Milunsky, A., Utilization of trophoblast for early prenatal diagnosis, in Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment (A. Milunsky, ed.), Plenum Press, New York (1979).
Rodeck, C. H., and Morsman, J. M., First-trimester chorion biopsy, Br. Med. Bull. 39(4):338 (1983).
Hsu, L. Y. F., and Perlis, T. E., United States survey on chromosome mosaicism and pseudomosaicism in prenatal diagnosis Prenatal Diagnosis 4:97 (1984).
Boué, J., Boué, A., and Lazar, P., Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortion, Teratology 12:11 (1975).
Milunsky, A., Prenatal detection of neural tube defects.-VI. Experience with 20,000 pregnancies, JAMA 244:2731 (1980).
Milunsky, A., and Alpert, E., Results and benefits of maternal serum alpha-fetoprotein screening, JAMA 252:1438 (1984).
Haddow, J. E., and Milunsky, A., Deregulation of screening for alpha-fetoprotein in pregnancy. N. Eng. J. Med. 310:1669 (1984).
Little, P. F. R., DNA analysis and the antenatal diagnosis of hemoglobinopathies, in Genetic Engineering I (R. Williamson, ed.), Academic Press, London (1981).
Woo, S. L. C., Kidd, V. J., Pam, Z. K., et al. (eds.), Banbury Conference on Recombinant DNA Applications to Human Disease ,Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 105 (1983).
Murray, J. M., Davies, K. E., Harper, P. S., et al. ,Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy, Nature 300:69 (1982).
Choo, K. H., Gould, K. G., Rees, D. J. G., et al. ,Molecular cloning of the gene for human anti-haemophilia factor IX, Nature 299:178 (1982).
Gusella, J. F., Wexler, N. S., Conneally, P. M., et al., A polymorphic DNA marker genetically linked to Huntington’s disease, Nature 306:234 (1983).
Woo, S. L. C., Lidsky, A. S., Guttler, F., et al. ,Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria, Nature 306:5939:151 (1983).
Honey, N. K., and Shows, T. B., The tumor phenotype and the human gene map, Cancer Genet. Cytogenet. 10(3):287 (1983).
Rodeck, C. H., Mibashan, R. S., Abramowicz, J., and Campbell, S., Selective feticide of the affected twin by fetoscopic air embolism, Prenatal Diagnosis 2:189 (1982).
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© 1985 Aubrey Milunsky and George J. Annas
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Milunsky, A. (1985). Prenatal Diagnosis. In: Milunsky, A., Annas, G.J. (eds) Genetics and the Law III. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4952-5_24
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DOI: https://doi.org/10.1007/978-1-4684-4952-5_24
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