Abstract
Central questions of the tumor immunologist pertain to the type and nature of antigens appearing in the malignant state and methods used to detect them. Monoclonal antibody (MAb) technology (Köhler and Milstein, 1975) provides investigators an opportunity to study virtually any immunogenic molecule with exact precision and has been successful in detecting human tumor antigens (Boss et al., 1983). Recently, hybridoma technology has been extended to the production of human MAbs (Olsson and Kaplan, 1980; Schlom et al., 1980; Croce et al., 1980; Glassy et al., 1981, 1983a; Sikora and Phillips, 1981; Edwards et al., 1982) and is being used to study human tumor antigens.
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Glassy, M.C., Handley, H.H., Royston, I. (1985). Design and Production of Human Monoclonal Antibodies to Human Cancers. In: Engleman, E.G., Foung, S.K.H., Larrick, J.W., Raubitschek, A.A. (eds) Human Hybridomas and Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4949-5_12
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DOI: https://doi.org/10.1007/978-1-4684-4949-5_12
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