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Cell-Driven Viral Transformation

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Book cover Human Hybridomas and Monoclonal Antibodies

Abstract

Since the advent of hybridoma technology, one of the most provocative applications for monoclonal antibodies has been immunotherapy. Early reports of experiments performed in mice suggested that monoclonal antibody therapy was beneficial against murine T-cell lymphoma (Bernstein et al., 1980) and that it might be useful to deliver potent toxins to undesirable cells in vivo [reviewed in Moller (1982)]. Murine monoclonals have more recently been administered without major adverse reactions to immunocompromised human patients with leukemia or lymphoma (Levy and Miller, 1983). Results from these studies have shown, however, that the therapeutic effects of these reagents were difficult to maintain, due in large part to a host response to mouse immunoglobulin (Ig) which resulted in accelerated clearance of successive doses (Levy and Miller, 1983). This observation together with the goal of prophylactically and therapeutically treating a broader group of human patients have provided incentive to develop human monoclonal technology.

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Authors and Affiliations

  1. Genetic Systems, Seattle, Washington, 98121, USA

    Anthony W. Siadak & Mark E. Lostrom

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  1. Anthony W. Siadak
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  2. Mark E. Lostrom
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Editors and Affiliations

  1. Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, 94305, Stanford, California, USA

    Edgar G. Engleman  & Steven K. H. Foung  & 

  2. Cetus Immune Research Laboratories, 94303, Palo Alto, California, USA

    James W. Larrick  & Andrew A. Raubitschek  & 

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© 1985 Plenum Press, New York

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Siadak, A.W., Lostrom, M.E. (1985). Cell-Driven Viral Transformation. In: Engleman, E.G., Foung, S.K.H., Larrick, J.W., Raubitschek, A.A. (eds) Human Hybridomas and Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4949-5_10

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  • DOI: https://doi.org/10.1007/978-1-4684-4949-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4951-8

  • Online ISBN: 978-1-4684-4949-5

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