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Human Hybridomas and Monoclonal Antibodies

The Biology of Cell Fusion

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Book cover Human Hybridomas and Monoclonal Antibodies

Abstract

In this review I will cover, from a cell biologist’s perspective, the biology of cell fusion and how the information derived from the field may be applicable to the production of human monoclonal antibodies. I will describe the development of the hybridoma technology, the advantages and disadvantages of making and using monoclonal antibodies, the methods and limitations of making human monoclonal antibodies, the freezing and thawing of hybridomas, and end with a discussion of chromosome segregation in cell hybrids.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, University of Texas Health Science Center at Dallas, Dallas, Texas, 75235, USA

    Jerry W. Shay

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  1. Jerry W. Shay
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Editors and Affiliations

  1. Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, 94305, Stanford, California, USA

    Edgar G. Engleman  & Steven K. H. Foung  & 

  2. Cetus Immune Research Laboratories, 94303, Palo Alto, California, USA

    James W. Larrick  & Andrew A. Raubitschek  & 

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© 1985 Plenum Press, New York

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Shay, J.W. (1985). Human Hybridomas and Monoclonal Antibodies. In: Engleman, E.G., Foung, S.K.H., Larrick, J.W., Raubitschek, A.A. (eds) Human Hybridomas and Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4949-5_1

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  • DOI: https://doi.org/10.1007/978-1-4684-4949-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4951-8

  • Online ISBN: 978-1-4684-4949-5

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