Abstract
Clinically, hemodilution may be induced under various circumstances such as intraoperatively during cariopulmonary bypass (1) or therapeutically (2,3). However, aside from its clear-cut efficacy in polycythemic patients (3) and in other pathologic circumstances (2), there is some doubt as to whether tissue oxygenation is improved by hemodilution to subnormal hematocrits (4). With regard to oxygen delivery to the myocardium, Lundsgaard-Hansen (4) concluded that hemodilution should not exceed the lower normal range of hemoglobin or hematocrit (Hct), namely, 12.0 to 12.5% and 35 to 36%, respectively. Our aim in this study was to determine the effects of progressive, normovolemic hemodilution with hydroxy ethyl starch over Hct ranging from 40 to 5% on cerebral cortical oxygenation and perfusion.
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© 1984 Plenum Press, New York
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Shinozuka, T., Nemoto, E.M., Bleyaert, A.L. (1984). Cerebral Cortical Oxygenation and Perfusion during Hetastarch Hemodilution. In: Bruley, D., Bicher, H.I., Reneau, D. (eds) Oxygen Transport to Tissue—VI. Advances in Experimental Medicine and Biology, vol 180. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4895-5_83
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DOI: https://doi.org/10.1007/978-1-4684-4895-5_83
Publisher Name: Springer, Boston, MA
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