Abstract
The increase in blood flow that occurs with stimulation of oxygen uptake in skeletal muscle is caused by at least three potential vasodilatory inputs to the area, according to Honig (1979). One of these, active sympathetic vasodilation, is dependent on extrinsic innervation and is usually seen as a transient response in anticipation of exercise. That would hardly apply in an anesthetized dog. The early increase in blood flow to contracting muscle in such a case can be attributed to the action of intrinsic nerves with neuronal cell bodies in the wall of small arteries and arterioles. The blood flow response would then be reinforced and sustained by metabolic vasodilation, which has a slower onset, in the unifying hypothesis of exercise vasodilation proposed by Honig. I thought that a rather neat test to this hypothesis could be made by chemically stimulating oxygen uptake in the hindlimb of an anesthetized dog by local injection of 2,4-dinitrophenol (DNP), an uncoupler of oxidative phosphorylation. This would avoid stimulation of intrinsic nerves while still supplying metabolic stimulation and would thus allow separation of the two potential vasodilator influences.
Supported by Research Grants HL 14693 and HL 26927, National Heart, Lung, and Blood Institute.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Banet, M. and Guyton, A.C., 1971, Effect of body metabolism on cardiac output; role of the central nervous system. Am. J. Physiol., 220:662–666.
Goodman, A.H., Einstein, R., and Granger, H.J., 1978, Effect of changing metabolic rate on local blood flow control in the canine hindlimb. Circ. Res., 43:769–776.
Granger, H.J. and Norris, C.P., 1980, Intrinsic regulation of intestinal oxygenation in the anesthetized dog. Am. J. Physiol. 238 (Heart Circ. Physiol. 7), H836–H843.
Honig, C.R., 1979, Contributions of nerves and metabolites to exercise vasodilation: a unifying hypothesis. Am. J. Physiol. 236 (Heart Circ. Physiol. 5), H705–H719.
Nuutinen, E.M., Nelson, D., Wilson, D.F., and Erecinska, M., 1983, Regulation of coronary blood flow: effects of 2,4-dinitrophenol and theophylline. Am. J. Physiol. 244 (Heart Circ. Physiol. 13), H396–H405.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Cain, S.M. (1984). Circulatory Responses to Chemical Stimulation of Oxygen Uptake in Canine Hindlimb. In: Bruley, D., Bicher, H.I., Reneau, D. (eds) Oxygen Transport to Tissue—VI. Advances in Experimental Medicine and Biology, vol 180. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4895-5_66
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4895-5_66
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4897-9
Online ISBN: 978-1-4684-4895-5
eBook Packages: Springer Book Archive