Abstract
Today there is a good deal of interest in oxygen and its role in carcinogenesis, mutagenesis and radiation response. Our laboratory has long been interested in one class of clinically useful drugs, the nitroaromatic heterocycles, which stimulate oxygen consumption in mammalian cells via metabolic reduction to oxygen-reactive radical anions (1,2). Figure 1 is a metabolic scheme for cellular reduction of the nitro compounds. This metabolism, and factors that influence it, has recently been reviewed by Biaglow (2) and by Mason (3).
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References
J.E. Biaglow, B. Jacobson, C.L. Greenstock and J. Raleigh, Effect of nitrobenzene derivatives on electron transfer in cellular and chemical models. Mol. Pharmacol., 13:269 (1977).
J.E. Biaglow, Cellular electron transfer and radical mechanisms for drug metabolism, Rad. Research, 86:212 (1981).
R.P. Mason, Free-radical intermediates in the metabolism of toxic chemicals, in “Free Radicals in Biology, Vol. V.” W.A. Pryor, ed., Academic Press, Inc., N.Y. (1982).
J.E. Biaglow, O.F. Nygaard and C.L. Greenstock, Electron transfer in Ehrlich ascites tumor cells in the presence of nitrofurans. Biochem. Pharmacol., 25:393 (1976).
M.E. Varnes, S.W. Tuttle and J.E. Blaglow, Nitroheterocycle metabolism in mammalian cells: Stimulation of the hexose monophosphate shunt, Blochem. Pharmacol. (in press).
C.B. Schroy and J.E. Biaglow, Use of an oxidase electrode to determine factors affecting the in vitro production of hydrogen peroxide by Ehrlich cells and l-chloro-2,4-dinitrobenzene. Biochem. Pharmacol., 30:320 (1981).
M.E. Varnes, S.W. Tuttle and J.E. Biaglow, The use of a peroxidase electrode to measure the effects of nitro compounds on intact cells, in “Oxygen Transport to Tissue — IV”, H. Bicher, ed., Plenum Press, N.Y. (1983).
J.E. Biaglow, M.E. Varnes, M. Astor, J. Mitchell and A. Russo, Intracellular thiols: Involvement in drug metabolism and radiation response, in “Radioprotectors and Anticarcinogens”, O.F. Nygaard and M.G. Simic, eds., Academic Press, Inc., N.Y. (1983).
J.E. Biaglow, M.E. Varnes, M. Astor and E.J. Hall, Nonprotein thiols and cellular response to drugs and radiation. Int. J. Rad. Oncol. Biol. Phys., 8:719 (1982).
E.A. Bump, N.Y. Yu, Y.C. Taylor, J.M. Brown, E.L. Travis and M.R. Boyd, Radiosensitization and chemosensitization by diethylmaleate, in “Radioprotectors and Anticarcinogens”, O.F. Nygaard and M.G. Simic, eds., Academic Press, Inc., N.Y. (1983).
B. Chance, Spectrophotometry of intracellular respiratory pigments. Science, 120:767 (1954).
B. Chance, H. Sies and A. Boveris, Hydroperoxide metabolism in mammalian organs. Physiological Reviews, 59:527 (1979).
J.G. Reich and E.E. Sel’kov, “Energy Metabolism of the Cell”, Academic Press, London (1981).
T. Galeotti, A Cittadini and B. Chance, NAD(P) redox compartmentation in Ehrlich ascites tumour cells. Biochim. Biophys. Acta, 267:1 (1972).
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© 1984 Plenum Press, New York
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Varnes, M.E., Biaglow, J.E., Donahue, L., Tuttle, S.W. (1984). Effects of Glucose and Thiol Depletion on Chemically-Induced Peroxide Production in Mammalian Cells. In: Bruley, D., Bicher, H.I., Reneau, D. (eds) Oxygen Transport to Tissue—VI. Advances in Experimental Medicine and Biology, vol 180. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4895-5_64
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DOI: https://doi.org/10.1007/978-1-4684-4895-5_64
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