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Augmentation and Facilitation of Oxygen Transfer in Flowing Hemoglobin Solutions

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Oxygen Transport to Tissue—VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 180))

Abstract

Oxygen transfer was studied in hemoglobin solutions in tube flow at wall shear rates between 200 s-1 and 1000 s-1. Measurements of the bulk oxygen transfer are compared with an analytical model including the effect of the carrier-facilitation of the hemoglobin. Over the range considered this increases the effective diffusion coefficient by almost a factor of three. The addition of hemolyzed red cells, keeping the total hemoglobin concentration constant, provided an additional increase in the effective diffusion coefficient of over 60%. This implies that a sizable increase occurs in the effective diffusion of the hemoglobin molecule, apparently due to the motion of the red cells in the shear field of the fluid. The increase in transport matches well with quantitative estimates of the translational motion of red blood cells.

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Authors and Affiliations

  1. Mechanical Engineering Department, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061, USA

    T. E. Diller, I. A. Pattantyus & W. C. Britts

Authors
  1. T. E. Diller
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  2. I. A. Pattantyus
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  3. W. C. Britts
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Editor information

Editors and Affiliations

  1. California Polytechnic State University, San Luis Obispo, California, USA

    Duane Bruley

  2. Western Tumor Medical Group, Van Nuys, California, USA

    Haim I. Bicher

  3. Louisiana Tech University, Ruston, Louisiana, USA

    Daniel Reneau

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© 1984 Plenum Press, New York

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Diller, T.E., Pattantyus, I.A., Britts, W.C. (1984). Augmentation and Facilitation of Oxygen Transfer in Flowing Hemoglobin Solutions. In: Bruley, D., Bicher, H.I., Reneau, D. (eds) Oxygen Transport to Tissue—VI. Advances in Experimental Medicine and Biology, vol 180. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4895-5_52

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  • DOI: https://doi.org/10.1007/978-1-4684-4895-5_52

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4897-9

  • Online ISBN: 978-1-4684-4895-5

  • eBook Packages: Springer Book Archive

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