Direct Effects of Oxygen Toxicity During the Cardiac “Oxygen Paradox”

  • Yarm Gauduel
  • Michel Duvelleroy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


One of the first manifestation of cardiac injury promoted by oxygen re-admission (“oxygen paradox”) is the abnormal reaction of hypoxic cells to molecular oxygen (Hearse et al., 1973, 1978; Gauduel et al., 1979). The role of actived metabolites of oxygen in the development of the oxygen-induced cardiac injury have been suggested by several authors (Guarnieri et al., 1980; Hess, 1981), but the mechanisms of oxygen toxicity processes are still imperfectly understood. There are no conclusive works which have ascertained the mechanisms of irreversible cardiac injury during reoxygenation (Ganote et al., 1979).


Creatine Kinase Cardiac Cell Cardiac Injury Cardiac Lipid Total Creatine Kinase 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Yarm Gauduel
    • 1
  • Michel Duvelleroy
    • 1
  1. 1.Laboratory of BiophysicsFernand Widal HospitalParisFrance

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