Cold Protected Hearts Extract Oxygen from Fluosol-DA During Cardiopulmonary Bypass
Cold cardioplegic solutions are used widely to help preserve the myocardium during the mandatory period of cardiac arrest required to perform most cardiac operations (Berger RL et al., 1981; Engelman RM et al., 1980; Conti VR et al., 1978). Providing the myocardium with oxygen during the elective ischemic period could prove beneficial. Adequate methods of providing oxygen have not readily been found. Cold oxygenated crystalloid cardioplegia (CP) and cold oxygenated blood CP have been used to deliver oxygen to the arrested heart. Engelman et al., (1980), reported higher levels of creatine phosphate in an isolated pig heart preparation after the use of oxygenated crystalloid cardioplegia solutions or oxygenated blood cardioplegia solutions as compared to an unoxygenated crystalloid solution. Bodenhamer et al., (1983), reported higher postperfusion levels of adenosine triphosphate, less myocardial water accumulation, as well as better functional preservation in dog hearts which received oxygenated crystalloid cardioplegia versus aerated crystalloid cardioplegia. The amount of oxygen that can be delivered to the myocardium by these methods is necessarily limited.
KeywordsCardioplegia Solution Oxyhemoglobin Dissociation Curve Surgical Arrest Crystalloid Cardioplegia Ischemic Arrest
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