Selective Anoxic Injury to Thick Ascending Limb: An Anginal Syndrome of the Renal Medulla?

  • Mayer Brezis
  • Seymour Rosen
  • Patricio Silva
  • Franklin H. Epstein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


Leichtweiss et al. and Baumgartl et al. (1,2) have previously shown that the partial pressure O2 in the tissue, as measured by platinum microelectrodes inserted into the rat or dog kidney from cortex to medulla, drops steeply in the cortico-medullary junction to values in the range of 10 to 20 mmHg in the medulla, both in vivo and during isolated perfusion. This steep cortico-medullary gradient of pO2 in kidney tissue is the result of the medullary vascular structure and the conditions imposed by the counter-current exchange system (3) as shown in Figure 1.


Renal Medulla Outer Medulla Thick Ascending Limb Platinum Microelectrode Ischemic Renal Injury 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Mayer Brezis
    • 1
    • 2
  • Seymour Rosen
    • 1
    • 2
  • Patricio Silva
    • 1
    • 2
  • Franklin H. Epstein
    • 1
    • 2
  1. 1.Departments of Medicine and Pathology Thorndike LaboratoryHarvard Medical SchoolBostonUSA
  2. 2.Beth Israel HospitalBostonUSA

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