Brain Responses to Experimental Oxygen Deficiency in the Mongolian Gerbil
Cerebral ischemia was investigated in the Mongolian gerbil due to the incompleteness of the Circle of Willis in this desert rodent (for details see ref. 1). Occlusion of the two carotid arteries in the gerbil may lead to complete cerebral ischemia due to the lack of connection between the basilar and carotid circulations. Under unilateral carotid artery occlusion (left or right) the level of ischemia to be developed is dependent upon the degree of connection between the two hemispheres through the arterior part of the Circle of Willis (1, 2). We adopted the gerbil as an experimental animal due to the ease in producing various levels of ischemia (ranging from minimal ischemia up to the complete one) and thus enabling the comparison with another oxygen deficiency insult-hypoxia.
KeywordsMongolian Gerbil Carotid Artery Occlusion Increase Blood Volume Gerbil Brain Corrected Fluorescence
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