Brain Responses to Experimental Oxygen Deficiency in the Mongolian Gerbil

  • A. Mayevsky
  • N. Zarchin
  • B. Tannenbaum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


Cerebral ischemia was investigated in the Mongolian gerbil due to the incompleteness of the Circle of Willis in this desert rodent (for details see ref. 1). Occlusion of the two carotid arteries in the gerbil may lead to complete cerebral ischemia due to the lack of connection between the basilar and carotid circulations. Under unilateral carotid artery occlusion (left or right) the level of ischemia to be developed is dependent upon the degree of connection between the two hemispheres through the arterior part of the Circle of Willis (1, 2). We adopted the gerbil as an experimental animal due to the ease in producing various levels of ischemia (ranging from minimal ischemia up to the complete one) and thus enabling the comparison with another oxygen deficiency insult-hypoxia.


Mongolian Gerbil Carotid Artery Occlusion Increase Blood Volume Gerbil Brain Corrected Fluorescence 
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  1. 1.
    A. Mayevsky, N. Zarchin, H. Kaplan, J. Haveri, J. Haselgrove, and B. Chance Brain Metabolic Responses to Ischemia in the Mongolian Gerbil: in Vivo and Freeze Trapped Redox Scanning Brain Res. in press (1983).Google Scholar
  2. 2.
    M.F. Donadio, P.B. Kozlowsk, H. Kaplan, H.M. Wisniewski and Majkowski, J., Brain vasculature and induced ischemia in seizure-prone and non-seizure prone gerbils, Brain Research. 234:263 (1982).PubMedCrossRefGoogle Scholar
  3. 3.
    C.M. Friedli, D.S. Sclarsky and A. Mayevsky. A new multi- probe assembly for surface monitoring of ionic metabolic and electrical activities in the awake brain. Am. J. Phvsiol. 243:R462 (1982).Google Scholar
  4. 4.
    A. Mayevsky, Multiparameter monitoring of the awake brain under hyperbaric oxygenation. J. AdI. Phvsiol. 54:740 (1983).Google Scholar
  5. 5.
    F.F. Jobsis, M. O’Connor, A. Vitale, and H. Verman. Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity. J. Neurophysiol. 34:735 (1971).PubMedGoogle Scholar
  6. 6.
    W. Crowe, A. Mayevsky, and L. Mela. Application of a solid membrane ion-selective electrode to in vivo measurements Am, J, Physiol, 233:C56 (1977).Google Scholar
  7. 7.
    D.V. Lewis, and W.H. Schulte. NADH fluorescence and (K+) changes during hippocampai stimulation. J. Neurophysiol. 38:405 (1975).PubMedGoogle Scholar
  8. 8.
    G.G. Somjen, M. Rosenthal, G. Cordingley, J. Lamanna, and E. Lothman. Potassium, neuroglia, and oxidative metabolism in central gray matter. Fed. Proc. 35:1266 (1976).PubMedGoogle Scholar
  9. 9.
    J. Astrup, L. Simon, N.M. Branston, and N.A. Lassen. Cortical evoked potential and extracellular K and H at critical levels of brain ischemia. Stroke 8:51 (1977).PubMedCrossRefGoogle Scholar
  10. 10.
    E. Leniger-Follert, R. Rubanics, K. Harbig and D.W. Lubbers. The behavior of local pH and NADH-fluorescence during and after direct activation of the brain cortex. In “Cerebral Function, Metabolism and Circulation” O.H. Ingvar, N.A. Lassen, eds. pp. 214–225, Munksgaard, Copenhagen, (1977).Google Scholar
  11. 11.
    E. Dora, T. Zeuthen, I.A. Silver, B. Chance, and A. G. B. Kovach. Effect of arterial hypoxia on the cerebrocortical redox state, vascular volume, oxygen tension, electrical activity and potassium ion concentration. Acta Physjol. Acad. Sci. Hung. 54:319 (1979).Google Scholar
  12. 12.
    A. Mayevsky and D. Sclarsky. Correlation of brain NADH redox state, K+, PO2 and electrical activity during hypoxia, ischemia and spreading depression. ISOTT Meeting, in press, (1983).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Mayevsky
    • 2
  • N. Zarchin
    • 1
  • B. Tannenbaum
    • 1
  1. 1.Dept. of Life SciencesBar Ilan UniversityRamat GanIsrael
  2. 2.Johnson Research FoundationMedical School University of PennsylvaniaPhiladelphiaUSA

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