Cerebral Oxygen Utilization as a Gauge of Brain Energy Metabolism
Few studies relate the function of cerebral mitochondria to brain energy metabolism due, in part, to the technical challenge of quantifying energy metabolism. In vivo methods depend on the fact that a change in oxygen supply to the brain results in the blockage of electron transport through the respiratory chain. Consequently, there are detectable changes in NADH1 and cytochrome a/a3 2 concentrations which may be measured optically from the brain surface. Although the equipment is complex and expensive, these methods are advantageous because they provide a less invasive, real time estimate of regional brain redox status. Nevertheless, these data are difficult to equate with either regional ATP turnover or global brain metabolism.
KeywordsOxygen Deficit Respiratory Control Ratio High Energy Phosphate Real Time Estimate Brain Energy Metabolism
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