Effect of Lactate and Pyruvate on Cerebrocortical Microcirculation and NAD/NADH Redox State

  • Eors Dora
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


In the past, several humoral vasodilatators, like H+, K+, adenosine, lactate, etc., have been suggested being responsible for the coupling between cerebral blood flow CCBF) and metabolism2,10,11,12,13. However, the exact mechanism of coupling is still obscure.The concentration of some of these vasodilatator substances is either not altered (Wahl and Kuschinsky17 and Winn et al.21: H+ and K+ concentrations in the perivascular space of pial arteries and cerebral adenosine content during moderate arterial hypotension) or altered later than CBF (Astrup et al.1 and Morii et al.12: H+, K+ and lactate concentrations during arterial hypoxia), or their increase can not explain entirely the elevation of CBF (Astrup et al.1, Dora et al.7, and Winn et al.21: K+ and adenosine concentrations during arterial hypoxia and epileptic seizures).Because it has been demonstrated that H+, K+, and adenosine are potent dilatators of the pial arteries2,11,16, but such data were not available for lactate, we investigated the vasodilatating efficacy of lactate.


Cerebral Blood Flow Brain Cortex Pial Artery Cranial Window NADH Fluorescence 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Eors Dora
    • 1
  1. 1.Cerebrovascular Research CenterUniversity of PennsylvaniaPhiladelphiaUSA

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