Distribution of Blood Flow in Partially Closed Cerebral Capillary Networks
The objective of the present study was to determine the direct effect of capillary closure on regional blood flow. Microcirculatory obstruction is a major factor influencing the evolution of cerebral infarction. It has been suggested that tissue swelling compresses primarily the microcirculation (Little et al., 1976), most likely at the site of the lowest blood pressure. Therefore, we have constructed a microcirculatory model which relates blood flow to the number of closed versus open capillaries. It was anticipated that the topological pattern of the microcirculatory vasculature network has an important role in determining the relationship between blood flow and the number of perfused microvessels which are reduced significantly in cerebral ischemia. Computer simulation as well as experimental techniques have been developed and applied to answer these questions.
KeywordsCapillary Density Regional Blood Flow Significant Linear Correlation Tissue Blood Flow Perfuse Capillary
Unable to display preview. Download preview PDF.
- 2.K. A. Conger, H.P. Moraes, E.R. Strong, K. Hino, L. Briggs, J.H. Garcia, J.H. Halsey Jr. Computer controlled blood pressure changes required for steady state oxygen control of partial ischemia in the rat brain cortex. ISOTT Proceedings 1983.Google Scholar
- 3.M.S. Burstone. Histochemical comparison of naphthol As-phosphates for the demonstration of phosphatases. J. Nat’l Cancer Institute, 20: 601–613 (1958)Google Scholar