Abstract
During the last two decades studies of the molecular mechanisms by which antibody diversity is generated have provided us with fundamental insights into the structure, organization and programmed movement of immunoglobulin genes during development (Potter et al., 1964; Dreyer et al., 1967; Hood et al., 1975; Huang and Dreyer; 1978; Leder, 1982). Progress in this specialized area of developmental biology has occurred far more rapidly than in any other developmental system. (An appreciation of the level of knowledge extant in 1967 may be obtained by reading the proceedings of the Cold Spring Harbor Symposium on Quantitative Biology, volume 32, 1967.) The depth of genetic and molecular understanding which has been gained in this field is due in large part to the existence of myelomas, tumors of antibody-producing cells, from which gram quantities of antibody molecules could easily be obtained. These amounts of protein were necessary and sufficient, given the methods and instrumentation available in the sixties, to do structural analyses and to obtain protein sequence information about these molecules.
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© 1984 Plenum Press, New York
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Dreyer, W.J., Roman, J., Teplow, D.B. (1984). New Instrumentation Facilitates the Study of Genes Coding for Molecules Involved in Cell Surface Recognition. In: Lauder, J.M., Nelson, P.G. (eds) Gene Expression and Cell-Cell Interactions in the Developing Nervous System. Advances in Experimental Medicine and Biology, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4868-9_14
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DOI: https://doi.org/10.1007/978-1-4684-4868-9_14
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