Abstract
We have studied a case of acute lymphocytic leukemia (L3 type) with 8;14 chromosome translocation. DNA obtained from peripheral blood leukemic cells was analyzed by restriction endonuclease mapping and hybridization with genomic or c-DNA human c-myc probes. The breakpoint of the translocation has been localized within the first intron of the c-myc gene,thus leaving the first untranslated exon on chromosome 8q− and rearranging the whole protein-coding region in the IgH locus on chromosome 14q+. Northern blot analysis showed high levels of two different c-myc transcripts originated from the translocated gene, which were not detected in WBC in remission phase. These studies demonstrate for the first time rearrangement and abnormal expression of a cellular one-gene (c-myc) in primary cells from an acute leukemia patient.
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Peschle, C. et al. (1984). Rearrangement and Abnormal Expression of Human c-myc in Acute Lymphocytic Leukemia. In: Aaronson, S.A., Frati, L., Verna, R. (eds) Genetic and Phenotypic Markers of Tumors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4856-6_30
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DOI: https://doi.org/10.1007/978-1-4684-4856-6_30
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