Skip to main content
SpringerLink
Log in
Book cover

Genetic and Phenotypic Markers of Tumors pp 235–259Cite as

The Relationships Between the High Production of Prostaglandins by Tumors and their Action on Lymphocytes as Suppressive Agents

  • Chapter

Abstract

The immune surveillance theory states that cancer cells having foreign antigens on their surfaces, are recognized and destroyed by cells of the immune system before they can grow into a life-threatening tumor. The foreign antigens would be recognized by the immune system triggering the production of cytotoxic T lymphocytes specifically directed against the antigens1.

Deceased, June 1983

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. H. Friedman, S. Specter, I. Kamo, and J. Kateley, Tumor-associated immunosuppressive factors, Ann. N.Y. Acad. Sci. 276: 417 (1976).

    Article  PubMed  CAS  Google Scholar 

  2. B.R. Bloom, Interferons and the immune system, Nature 284: 593 (1980).

    Article  PubMed  CAS  Google Scholar 

  3. R. Kiessling, E. Klein and H. Wigzell, Natural Killer cells in the mouse. Cytotoxic cells with specificity for mouse maloney leukemia cells: specificity and distribution according to genotype, Europ. J. Immunol. 5: 112 (1975).

    Article  CAS  Google Scholar 

  4. R. B. Herberman and H. T. Holden, Natural Killer cells as antitumor effector cells, J. Natl. Cancer Inst. 62: 441 (1979).

    PubMed  CAS  Google Scholar 

  5. O. J. Plescia, A. H. Smith and K. D. Grinwich, Subversion of immune system by tumor cells and the role of prostaglandins, Proc. nat. Acad. Sci. USA 72: 1848 (1975).

    Article  PubMed  CAS  Google Scholar 

  6. S. M. M. Karim and B. Rao, Prostaglandins and tumors, Adv. Prostaglandin Res. 3: 303 (1976).

    Google Scholar 

  7. J. S. Goodwin and D. R. Webb, Regulation of the immune response by prostaglandins, Clin. Immunol. Immunopath. 15: 106 (1980).

    Article  CAS  Google Scholar 

  8. J. C. Roder and M. Klein, Target effector interaction in the natural killer cell system, J. Immunol. 123: 2785 (1979).

    PubMed  CAS  Google Scholar 

  9. M. J. Brunda, R. B. Herberman and H. T. Holden, Inhibition of murine natural killer cell activity by prostaglandins, J. Immunol. 124: 2682 (1980).

    PubMed  CAS  Google Scholar 

  10. V. Tomasi, G. Bartolini, M. Orlandi, C. Meringolo and O. Barnabei, Mechanism of action and biological significance of prostaglandin E2 and prostacyclin in the liver, in: “Lipoprotein metabolism and Endocrine regulation”, L. W. Hessel and H. M. J. Krans, eds., Elsevier-North Holland, Amsterdam, 279 (1979).

    Google Scholar 

  11. G. Bartolini, C. Meringolo, M. Orlandi and V. Tomasi, Biosynthesis of prostaglandins in parenchymal and non-parenchymal rat liver cells, Biochim. Biophys. Acta 530: 325 (1978).

    CAS  Google Scholar 

  12. V. Tomasi, C. Meringolo, G. Bartolini and M. Orlandi, Biosynthesis of prostacyclin in rat liver endothelial cells and its control by prostaglandin E2, Nature 273: 670 (1978).

    Article  PubMed  CAS  Google Scholar 

  13. A. Trevisani, A. Ferretti, A. Capuzzo and V. Tomasi, Elevated levels of prostaglandin E2 in Yoshida hepatoma and the inhibition of tumor growth by non steroidal anti-inflammatory drugs, Br. J. Cancer 41: 341 (1980).

    Article  PubMed  CAS  Google Scholar 

  14. A. Capuzzo, A. Corallini, E. Fabbri, M. E. Ferretti, M. Pareschi, V. Tomasi and A. Trevisani, Osservazioni preliminari sulla biosintesi in vitro di prostaglandine di tipo E in cellule tumorali e trasformate da virus, Boll. Soc. It. Biol. Sper 57: 2104 (1981).

    CAS  Google Scholar 

  15. J. W. Smith, A. L. Steiner and C. W. Parker, Human lymphocytic metabolism. Effects of cyclic and non cyclic nucleotides on stimulation by phytohaemagglutinin, J. Clin. Invest. 50: 442 (1971).

    Article  PubMed  CAS  Google Scholar 

  16. J. D. Stobo, M. S. Kennedy and M. E. Goldyne, Prostaglandin E modulation of the mitogenic response of human T cells, J. Clin. Invest. 64: 1188 (1979).

    Article  PubMed  CAS  Google Scholar 

  17. A. Novogrodsky, A. L. Rubin and K. H. Stenzel, Selective suppression by adherent cells, prostaglandin and cyclic AMP analogues of blastogenesis induced by different mitogens, J. Immunol. 122: 1 (1979).

    PubMed  CAS  Google Scholar 

  18. J. S. Goodwin, S. Bromberg and R. P. Messner, Studies on the cyclic AMP response to prostaglandin in human lymphocytes, Cell. Immunol. 60: 298 (1981).

    Article  PubMed  CAS  Google Scholar 

  19. D. R. Webb, T. J. Rogers and I. Nowowiesky, Endogenous prostaglandin synthesis and the control of lymphocyte function, Proc. N.Y. Acad. Sci. 332; 262 (1980).

    Article  Google Scholar 

  20. P. Y. K. Wong, J. C. McGiff, F. F. Sun and W. H. Lee, 6-ketoprostaglandin E1 inhibits the aggregation of human platelets, Eur. J. Pharmacol. 60: 245 (1979).

    Article  PubMed  CAS  Google Scholar 

  21. P. Y. K. Wong, K. U. Malik, D. M. Desiderio, J. C. McGiff and F. F. Sun, Hepatic metabolism of prostacyclin (PGI2) in the rabbit: formation of a potent novel inhibitor of platelet aggregation, Biochem. Biophys. Res. Commun. 93: 486 (1980).

    Article  PubMed  CAS  Google Scholar 

  22. S. Fadda, R. Mastacchi, G. Romeo, V. Tomasi and O. Barnabei, Regulation of cyclic AMP levels in human lymphocytes and lymphoblasts by prostaglandins, Prost. and Med. 5: 477 (1980).

    Article  CAS  Google Scholar 

  23. R. Mastacchi, S. Fadda, V. Tomasi and O. Barnabei, The effect of 6-keto-PGE1 on human lymphocyte cyclic AMP levels, Prost. and Med. 5: 487 (1980).

    Article  CAS  Google Scholar 

  24. W. E. Lands and B. Samuelsson, Phospholipids precursors of prostaglandins, Biochim. Biophys. Acta 164: 426 (1968).

    PubMed  CAS  Google Scholar 

  25. M. Hamburg, B. Samuelsson, On the metabolism of PGE1 and PGE2 in man, J. Biol. Chem. 246: 6713 (1971).

    Google Scholar 

  26. K. V. Honn, R. S. Bockman and L. J. Marnett, Prostaglandins and cancer. A review of tumor initiation through tumor metastasis, Prostaglandins 31: 833 (1981).

    Article  Google Scholar 

  27. P. Polgar, J. Carlos Vera and A. M. Rutenburg, An altered response to cyclic AMP stimulating hormones in intact human leukemic lymphocytes, Proc. Soc. Exp. Biol. Med. 154: 493 (1977).

    PubMed  CAS  Google Scholar 

  28. C. R. Kahn, Membrane receptors for hormone and neurotransmitters, J. Cell Biol. 70: 261 (1976).

    Article  PubMed  CAS  Google Scholar 

  29. C. W. Parker, Control of lymphocyte function, New Engl. J. of Medic. 295 (21): 1180 (1976).

    CAS  Google Scholar 

  30. J. H. Sanner and K. E. Eakins, Prostaglandin antagonists in: “Prostaglandins: Chemical and biochemical aspects”, S. M. M. Karim, ed., MTP, Lancaster, 139–187 (1976).

    Google Scholar 

  31. D. E. Mac Intyre and J. L. Gordon, Discrimination between platelet prostaglandin receptors with a specific antagonist of bisenoic prostaglandins, Thrombosis Res. 11: 705 (1977).

    Article  Google Scholar 

  32. G. C. Le Breton, D. L. Venton, E. S. Enke and P. V. Halushka, 13 Azoprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor, Proc. Natl. Acad. Sci. USA 76: 4097 (1979).

    Article  PubMed  Google Scholar 

  33. D. A. Langs, M. Erman and G. T. De Titta, Conformations of PGF2a and recognition of prostaglandins by their receptors. Science 197: 1003 (1977).

    Article  PubMed  CAS  Google Scholar 

  34. N. H. Andersen, S. Inamoto, N. Subramanian, D. H. Picker et al., Molecular basis forp prostaglandin potency. III. Tests of the significance of the “Hairpin conformation” in biorecognition phenomena, Prostaglandins 22 (5): 841 (1981).

    Article  PubMed  CAS  Google Scholar 

  35. D. Brewster, M. Myers, J. Ormerod, A. C. B. Smith, M. E. Spinner and S. Turber, Prostaglandin synthesis design and execution, J. Chem. Soc. Perkin 1: 2796 (1973).

    Article  Google Scholar 

  36. M. Baumgarth and K. Irmscher, Secoandrostansäuren als enantiomere prostaglandin-analoga-I, Tetrahedron 31: 3109 (1975).

    Article  CAS  Google Scholar 

  37. G. M. Milne and M. R. Johnson, Levonantradol: a role for central prostanoid mechanisms, J. Clin. Pharmacol. 21 (S): 367S (1981).

    PubMed  Google Scholar 

  38. F. A. Fitzpatrick, G. L. Bundy, R. R. Gorman and T. Honohan, 9,11 Epoxy-Iminoprosta-5,13-Dienoic acid is a thromboxane A2 antagonist in human platelets, Nature 275: 764 (1978).

    Article  PubMed  CAS  Google Scholar 

  39. V. A. Ferraris and F. R. De Rubertis, Release of prostaglandin by mitogen-and antigen-stimulated leukocytes in culture, J. Clin. Invest. 54: 378 (1974).

    Article  PubMed  CAS  Google Scholar 

  40. T. Okasaki,S. Masatoshi, C. E. Arbesman and E. Jr. Middleton, Prostaglandin E and mitogenic stimulation of human lymphocytes in serum-free medium, Prostaglandins 15 (3): 423 (1978).

    Article  Google Scholar 

  41. J. S. Goodwin, A. D. Bankhurst, R. P. Messner, Suppression of human T cell mitogenesis by prostaglandin E. E.istence of a prostaglandin producing suppressor cell, J. Exp. Med. 146: 1719 (1977).

    Article  PubMed  CAS  Google Scholar 

  42. J. S. Goodwin, R. P. Messner, A. D. Bankhurst, G. T. Peake, J. H. Saiki and R. C. Williams Jr, Prostaglandin producing suppressor cells in Hodgkin’s disease, New Eng. J. Med. 297: 263 (1977).

    Article  Google Scholar 

  43. J. S. Goodwin, A. Wiik, M. Lewis, A.D. Bankhurst and C. R. Williams Jr, High affinity binding sites for prostaglandin E on human lymphocytes, Cell Immunol. 43: 150 (1979).

    Article  PubMed  CAS  Google Scholar 

  44. J. S. Goodwin, P. A. Kaszubowski and C. R. Williams Jr, Cyclic adenosine monophosphate response to prostaglandin E2 on sub-population of human lymphocytes, J. Exp. Med. 150: 1260 (1979).

    Article  PubMed  CAS  Google Scholar 

  45. K. H. Leung, D. G. Fischer and H. S. Koren, Erythromyeloid tumor cells (K 562) induce PGE synthesis in human peripheral blood monocytes, J. Immunol. 131 (1): 445 (1983).

    PubMed  CAS  Google Scholar 

  46. R. M. Schultz, N. A. Pavlidis, W. A. Stylos and M. A. Chirigos, Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series, Science 202: 320 (1978).

    Article  PubMed  CAS  Google Scholar 

  47. W. F. Stenson and C. W. Parker, PG s, Macrophages and Immunity, J. Immunol. 125: 1 (1980).

    PubMed  CAS  Google Scholar 

  48. M. E. Goldyne and J. D. Stobo, PGE2 as a modulator of macrophage-T lymphocyte interactions, J. Invest. Dermatol. 74: 297 (1980).

    Article  PubMed  CAS  Google Scholar 

  49. D. S. Snyder, D. I. Beller and E. R. Unanne, Prostaglandins modulate macrophage Ia expression, Nature 299: 163 (1982).

    Article  PubMed  CAS  Google Scholar 

  50. M. E. Snider, R. H. Fertel, and B. S. Zwilling, Prostaglandin regulation of macrophage function: effect of endogenous and exogenous prostaglandins, Cell Immunol. 74: 234 (1982).

    Article  PubMed  CAS  Google Scholar 

  51. S. M. Taffet and S. W. Russell, Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by PGE, J. Immunol. 126: 424 (1981).

    PubMed  CAS  Google Scholar 

  52. O. J. Plescia, K. Grinwich, J. Sheridan and A. M. Plesia, Subversion of the immune system by tumors as a mechanism of their escape from immune rejection, Prog. Biochem. Pharmacol. 14: 123 (1978).

    CAS  Google Scholar 

  53. T. Goto, R. B. Herberman, A. Maluish and D. M. Strong, Cyclic AMP as a mediator of Prostaglandin E-induced suppression of human natural killer cell activity, J. Immunol. 130 (3): 1350 (1983).

    PubMed  CAS  Google Scholar 

  54. I. Mahnud, N. Fukui and Y. Miura, Arachidonic acid metabolism in normal and regenerating liver and hepatoma, Adv. Enzyme Regul. 18: 27 (1980).

    Article  Google Scholar 

  55. Y. Kanzeki, I. Mahnud, M. Asanagi, N. Fukui and Y. Miura, Thromboxane B2 as possible trigger of liver regeneration, Cell Mol. Biol. 25: 147 (1979).

    Google Scholar 

  56. J. S. Goodwin, Prostaglandin synthetase inhibitors as immunoadjuvants in the treatment of cancer, J. Immunopharmacol. 2: 397 (1980).

    Article  PubMed  CAS  Google Scholar 

  57. M. R. Young and S. Henderson, Enhancement in immunity of tumor bearing mice by immunization against PGE2, Immunol. Commun. 11: 345 (1982).

    PubMed  CAS  Google Scholar 

  58. A. Fischer, A. Durandy and C. Griscelli, Role of prostaglandin E2 in the induction of non specific T lymphocyte suppressor activity, J. Immunol. 126: 1452 (1981).

    PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. R. Mastacchi

    Present address: Alfa Farmaceutici, Bologna, Italy

  2. S. Fadda

    Present address: Neurological Clinic, University of Bologna, Italy

Authors and Affiliations

  1. Lab. of General Physiology, University of Bologna, Italy

    V. Tomasi, G. Bartolini & O. Barnabei

  2. Central Laboratory of the Hospital Malpighi, Bologna, Italy

    F. Barboni

  3. Institute of General Physiology, University of Ferrara, Italy

    M. C. Pareschi

  4. Istituto dei composti del Carbonio contenenti eteroatomi e loro applicazioni, C.N.R., Ozzano Emilia, Bologna, Italy

    S. Rossini

Authors
  1. V. Tomasi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Mastacchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Bartolini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Fadda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. Barnabei
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. Gatto
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F. Barboni
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. Trevisani
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. Capuzzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. E. Ferretti
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. M. C. Pareschi
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. G. Martelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. R. Danieli
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. S. Rossini
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Stuart A. Aaronson

  2. Institute of General Pathology, Rome, Italy

    Luigi Frati  & Roberto Verna  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Tomasi, V. et al. (1984). The Relationships Between the High Production of Prostaglandins by Tumors and their Action on Lymphocytes as Suppressive Agents. In: Aaronson, S.A., Frati, L., Verna, R. (eds) Genetic and Phenotypic Markers of Tumors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4856-6_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4856-6_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4858-0

  • Online ISBN: 978-1-4684-4856-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation