Abstract
It is well know that Interferon (IF) has antitumor activity presumably based on different mechanisms of action. This class of compounds is capable of inhibiting the growth of neoplastic cells (1), and of enhancing the cytotoxic activity mediated by natural killer (NK) lymphocytes (2,3) and by activated macrophages (4). However, additional studies have shown that a decrease of the susceptibility of normal or neoplastic cells to NK attack occurs after in vitro pretreatment with IF (5,9). These findings indicate that IF interacts in some way with NK target structures (NKTS) on the cell membrane, modifying their expression, or affinity, for effector lymphocytes. A number of studies pointed out that IF pretreatment of the target produces a profound influence on the antigenic makeup of tumor cells, increasing the expression of histocompatibility antigens specified by the major histocompatibility complex (MHC) both in mice (10) and in humans (11, 13). More detailed studies showed that two subsets of class II Molecules specified by DR and DC loci of human MHC, are differentially susceptible to IF-mediated modulation. DC products were found to be increased more than DR products under the influence of gamma-IF (14). These observations prompted us to investigate whether IF would also be able to produce differential effects on distinct subsets of NKTS. Actually, the results of the present paper support this hypothesis and suggest that different cell lines contain non-cross reacting NKTS susceptible to IF-mediated modulation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gresser I., Brouty-Boye D., Thomas M.T., and Marcieira Coelho A., 1970, Interferon and cell division. I. Inhibition of the multiplication of mouse Leukemia L1210 cells in vitro by interferon preparation. Proc. Natl. Acad., 66, 1052.
Riccardi C., Santoni A., Barlozzari T., Puccetti P., and Herbermann R.B., 1980, In vivo natural reactivity of mice against tumor cells. Int. J. Cancer, 25, 475.
Roder J.C., Karre K., and Kiessling R., 1981, Natural killer cells, Prog. Allerg. 28, 66.
Gresser I., Interferon and the immune-system. Immunology 80M Fourgereau J. Dausset (ed.), 1980, Progress in immunology, Ac. Press. IV, 710.
Trinchieri G., and Santoli D., 1978, Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-trasformed cells. Enhancement of human natural killer cell activitu by interferon and antagonistic inhibition of suceptibility of target cells to lysis. J. Exp. Med., 147, 1314.
Welsh R. M., and Hallenbeck L.A., 1980, Effect of virus infections on target cell susceptibility to natural killer cell-mediated lysis. J. Immunol. 124 (5), 2491.
Moore M., White W.J., and Potter M.R., 1980, Modulation of target cell susceptibility to human natural killer cells by interferon. Int. J. Cancer, 25, 565.
Trinchieri G., Granato D., and Perussia B., 1981, Interferon-induced resistance of librblasts to cytolysis mediated by NK cells: specificity and mechanism. J. Immunol., 126, (1), 219.
Welsh R.M., Karre K., Hansson M., Kunkel L.A., and Kiessling R.W., 1981, Interferon-mediated protection of normal and tumor target cells against lysis by mouse natural killer cells. J. Immunol. 126 (1), 219.
Sonnenfeld G., Meruelo D., Mc Devitt M.O., and Merigan T.C., 1981, Effect of type I and type II interferons on murine thymocytes surface antigen expression: induction or selection? Cell. Immunol., 57, 427.
Heron I., Hokland M., and Berg K., 1978, Enhanced expression of p2-microglobulin and HLA antigens on human lymphoid cells by interferon. Proc. Natl. Acad. Sci. USA, 75, 6215.
Dolei A., Ameglio F., Capobianchi M.R., and Tosi R., 1981, Human ß-Type interferon enhances the expression and shedding of Ia-like antigens Comparison to HLA-A, B, C and p2-microglobulin Antiviral. Res. 1; 367.
Dolei A., Capobianchi M.R., and Ameglio F., 1983, Human interferon-enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively then interferon- and interferon-B. Infect. Immun. 40, 172.
Ameglio F., Capobianchi M.R., Dolei A., and Tosi R., 1983, Differential effects of interferon-y on expression of HLA class II molecules controlled by the DR and DC Loci. Infect. Immun., 42, 122.
Cikes M., Friberg S. Jr., and Klein G., 1973, Progressive loss of H-2 antigens with concomitant increase of cell-surface antigen(s) determined by Moloney leukemia virus in cultured murine lymphomas. J. Natl. Cancer Inst. 50, 347.
Gresser I., Tovey M.G., Bandu M.T., Maury C., and Brouúyboye D., 1976, Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J. Exp. Med. 144, 1305.
Julius M.H., Simpson E., and Herzenberg L.A., 1973, A rapid method for the isolation of functional thymus-derived murine lymphocytes. Europ. J. Immunol. 3, 645.
Stulting R.D., and Berke G., 1973, Nature of lymphocyte-tumor interaction. A general method for cellular immunoabsorption. J. Exp. Med. 137, 932.
Kumar V., Luevano E., and Bennett M., 1979, Hybrid resistance to EL-4 lymphoma cells. I. Characterization of natural killer cells that lyse EL-4 cells and their distinction from marrow-dependent natural killer cells. J. Exp. Med. 150, 531.
Herbermann R.B., Aoki T., Nunn M., Lavrin D.H., Soares N., Gadfr A., Holden H., and Chang K.S.S., 1974, Specificity of Cr-release cytotoxicity of lymphocytes immune to murine sarcoma virus. J. Natl. Cancer Inst. 53, 1103.
Herbermann R.B., Aoki T., Nunn M., Lavrin D.H., Soares N., Gadfr A., Holden H., and Chang K.S.S., 1974, Specificity of 51Cr-release cytotoxicity of lymphocytes immune to murine sarcoma virus. J. Nat. Cancer Inst. 53, 1103.
Cerottini J.C., and Brunner K.T., 1974, Cell-mediated cytotoxicity allograft, rejection and tumor immunity. Advanc. Immunol. 18, 67.
Thorn R.M., and Henney C.S., 1976, Kinetic analysis of target cell destruction by effector T cells. I. Delineation of parameters related to the frequency and lytic efficiency of killer cells. J. Immunol. 117, 2213.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Graziani, G., Grandori, C., Macchi, B., Pastore, S., Bonmassar, E., Bonmassar, A.G. (1984). Interferon-Mediated Regulation of the NK Target Structures of Normal or Lymphoma Cells. In: Aaronson, S.A., Frati, L., Verna, R. (eds) Genetic and Phenotypic Markers of Tumors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4856-6_20
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4856-6_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4858-0
Online ISBN: 978-1-4684-4856-6
eBook Packages: Springer Book Archive