Abstract
The immunomodulators include a variety of biological and chemical compounds whose mechanisms of action involve the individual’s own biological responses. A modifier of the immune response should possess the following requirements:
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lack of carcinogenicity or tumor enhancing influence;
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no antigenicity;
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defined effects on the components of the immune system;
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known pharmacology;
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low experimental and clinical toxicity.
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References
Bruley-Rosset M., Rappaport H. (1983) Natural killer cell activity and spontaneous lymphoma development. Effects of single and multiple injections of interferon in young and aged C5761/6 mice. Int. J. Cancer 31, 381.
Chirigos M.A., Mastrangelo M.J. (1982) Immunorestoration by chemicals. In Immunological Approaches to Cancer Therapeutics, E. Mihich Ed, J. Wiley a Sons, New York, 191.
Chirigos M.A., Schlick E., Piccoli M., Read E., Hartung K., Bartocci A. (1983) Characterization of Agents. In Advances in Immunopharmacology, J. Hadden et al. Eds. Pergamon Press, 669.
De Landazuri M.O. and R.B. Herberman (1973) Immune response to Gross virus-induced lymphoma. III. Characterization of the cellular immune response. J. Natl. Cancer Inst. 49, 147.
Djeu J.Y., Heinbaugh J.A., Holden H.T. and R.B. Herberman (1979) Augmentation of mouse natural killer cell activity by interferon and interferon inducers. J. Immunol. 122, 175.
Droller M.J., Schneider M.V. and P. Perlman (1978) A possible role of prostaglandins in natural and antibody-dependent lymphocyte mediated cytotoxicity against tumor cells. Cell. Immunol. 37, 165.
Julius M.H., Simpson E., Herzenberg L.A. (1973) A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur. J. Immunol. 3, 645.
Kumagai K., Itoh K., Suzuki R., Hiruma S. and F. Saitoh (1982) Studies of murine large granular lymphocytes. I. Identification as effector cell in NK and K cytotoxicities. J. Immunol. 129, 2788.
Leung K.H., Koren H.S. (1982) Regulation of human natural killing. II. Protective effect of interferon on NK cells from suppression of PGE. J. Immunol. 129, 1742.
Luini W., Boraschi D., Alberti S., Aleotti A. and A. Tagliabue (1981) Morphological characterization of a cell population responsible for natural killer activity. Immunology 127, 282.
Maluish A.E., Coulon J., Ortaldo J.R., Sherwin S.A., Seavitt R., Fein S., Weirnick P., Oldham R.K. and R.B. Herberman (1982) Modulation of NK and monocyte activity in advanced cancer patients receiving interferon. In Interferons, T.C. Merigan aR.M. Friedman Eds. Academic Press, New York, 377.
Mathe’ G. (1978) Immunotherapy: experimental and rational basis. In Immunotherapy of human cancer, M.D. Anderson Ed, Raven Press New York, 5.
Ojo E., Haller O., Kimura A. and H. Wigzell (1978) An analysis of conditions allowing corynebacterium parvum to cause either augmentation or inhibition of natural cell activity against tumor cells in mice. Int. J. Cancer 21, 444.
Piccoli M., Saito T., and M.A. Chirigos (1984) Bimodal effects of MVE-2 on cytotoxic activity of Natural Killer cell and macrophage tumoricidal activity. Int. J. Immunopharmacol. in press.
Reinhart J.J., Wilson H.F., Neidhart J.A. (1982) Phase I evaluation of MVE-2 in man. Proc. Am. Soc. Clin. Oncol. 1, 37 (C 145)
Rios A., Rosenblum M.L., Powell M. and E. Hersh (1982) Phase I. Study with MVE-2 therapy in human cancer. Proc. Am. Soc. Clin. Oncol. 1, 37 (c-146).
Rosenberg S.A., Terry W.D. (1977) Passive immunotherapy of cancer in animals and in man. Adv. Cancer Res. 25, 323
Santoni A., Riccardi C., Barlozzari T. and R.B. Herberman (1980) Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer. Int. J. Cancer 26, 837.
Timonen T., Saksela E., Ranki A. and P. Hayry (1981) Characteristics of human large granular lymphocytes and relationship to natural killer and K cells. J. Exp. Med. 153, 569.
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© 1984 Plenum Press, New York
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Piccoli, M., Santoni, A., Velotti, F., Galli, M.C., Frati, L., Chirigos, M.A. (1984). Hyporesponsiveness of Natural Killer Activity Induced in Vivo By Multiple Treatment with Maleic Acid Anhydride Divinyl Ether (MVE-2). In: Aaronson, S.A., Frati, L., Verna, R. (eds) Genetic and Phenotypic Markers of Tumors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4856-6_18
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DOI: https://doi.org/10.1007/978-1-4684-4856-6_18
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