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Genetic Origin, Immunobiology, and Gonadotropin Expression in Trophoblast and Nontrophoblast Neoplasms

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Human Trophoblast Neoplasms

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 176))

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Abstract

A sequence of chronologic steps leading to the identification of exclusively paternal chromosomes in most hydatidiform moles has been developed. It had long been recognized that most moles were chromatin-positive at the nuclear margin. This was confusing, however, since one would ordinarily expect a 50:50 ratio of chromatin-positive to chromatin-negative moles. The initial large study by Baggish and Woodruff (1) on moles treated in Singapore revealed that all 90 moles studied showed well-defined heterochromatin bodies.

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  1. Department of Gynecology and Obstetrics, Medical College of Wisconsin, 8700 W. Wisconsin Avenue, Milwaukee, WI, 53226, USA

    Roland A. Pattillo

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  1. Department of Gynecology and Obstetrics, The Medical College of Wisconsin, 8700 W. Wisconsin Avenue, 53226, Milwaukee, Wisconsin, USA

    Roland A. Pattillo  & Robert O. Hussa  & 

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© 1984 Plenum Press, New York

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Pattillo, R.A. (1984). Genetic Origin, Immunobiology, and Gonadotropin Expression in Trophoblast and Nontrophoblast Neoplasms. In: Pattillo, R.A., Hussa, R.O. (eds) Human Trophoblast Neoplasms. Advances in Experimental Medicine and Biology, vol 176. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4811-5_3

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  • DOI: https://doi.org/10.1007/978-1-4684-4811-5_3

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