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Human Trophoblast Neoplasms pp 355–367Cite as

Re-Evaluation of 5-Fluorouracil as a Single Agent for Gestational Malignant Trophoblastic Neoplasms

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 176))

Abstract

It has been more than 20 years since 6-mercaptopurine was successfully used for the first time in the treatment of malignant trophoblastic neoplasms in the Capital Hospital in 1958. Since then, a total of four effective drugs have been found, and a dramatic improvement in prognosis of the patients has been achieved, resulting in permanent cure of this group of tumors. The overall results of treatment were reported in 1979 (1). To provide a general principle for the selection of a proper chemotherapeutic agent for clinical use, it is mandatory to evaluate each drug individually. The purpose of this paper is to present the therapeutic results of 5-fluorouracil used as a single agent in the treatment of malignant trophoblastic neoplasms.

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References

  1. Sung, H. C., Xia, Z. F., Wu, P. C., and Wang, Y. E., 20 years experience in chemotherapy of choriocarcinoma and malignant mole, Chinese Medical Journal 92: 677 (1979).

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  2. Sung, H. C., Wu, P. C., and Ho, T. H., Treatment of choriocar- cinoma and chorioadenoma destruens with 6MP and surgery, a clinical report of 67 cases, in: “Selected Papers on Cancer Research,” edited by Chinese Academy of Medical Sciences, Shanghai Sci. Tech. Publ. (1962), p. 441; republished in Acta Unio Inter-nationalis Contra Cancerum 20:491 (1964).

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  3. Zubrod, C. G., Effects of 5FU and 5FUDR on G-I cancer, J. Amer. Med. Assoc. 178: 832 (1961).

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  4. Sullivan, R. D., “Clinical Cancer Chemotherapy Including Ambulatory Infusion,” Charles C. Thomas, Publisher, Springfield, III. (1970), p. 50, p. 87.

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology Capital Hospital, Chinese Academy of Medical Sciences, Peking, China

    Hung-Chao Sung, Pao-Chen Wu & Yuan-Bh Wang

Authors
  1. Hung-Chao Sung
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  2. Pao-Chen Wu
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  3. Yuan-Bh Wang
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Editor information

Editors and Affiliations

  1. Department of Gynecology and Obstetrics, The Medical College of Wisconsin, 8700 W. Wisconsin Avenue, 53226, Milwaukee, Wisconsin, USA

    Roland A. Pattillo  & Robert O. Hussa  & 

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© 1984 Plenum Press, New York

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Sung, HC., Wu, PC., Wang, YB. (1984). Re-Evaluation of 5-Fluorouracil as a Single Agent for Gestational Malignant Trophoblastic Neoplasms. In: Pattillo, R.A., Hussa, R.O. (eds) Human Trophoblast Neoplasms. Advances in Experimental Medicine and Biology, vol 176. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4811-5_21

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  • DOI: https://doi.org/10.1007/978-1-4684-4811-5_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4813-9

  • Online ISBN: 978-1-4684-4811-5

  • eBook Packages: Springer Book Archive

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