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Human Trophoblast Neoplasms pp 271–287Cite as

Paradoxical Effect of Antibodies Against Chorionic Gonadotropin on BeWo Choriocarcinoma Cells in Vitro and in Vivo: Evidence for Heterogeneity of Cell Types

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 176))

Abstract

Human chorionic gonadotropin (hCG), a major hormone of early pregnancy, is also secreted by a variety of trophoblastic and nontrophoblastic tumors (1–3). Anti-hCG immunization has been proposed as an approach for control of fertility (4–6). The impact of anti-hCG immunization on tumors making hCG is a matter of concern. The antibodies could have an enhancing effect as noticed for some tumors (7), or could exercise a cytotoxic action on cancer cells secreting this hormone, especially in view of the report on localization of hCG on the surface of tumor cells (8).

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Authors and Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences and National Institute of Immunology, New Delhi, 110 029, India

    S. K. Gupta & G. P. Talwar

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  1. S. K. Gupta
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  2. G. P. Talwar
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Editors and Affiliations

  1. Department of Gynecology and Obstetrics, The Medical College of Wisconsin, 8700 W. Wisconsin Avenue, 53226, Milwaukee, Wisconsin, USA

    Roland A. Pattillo  & Robert O. Hussa  & 

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© 1984 Plenum Press, New York

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Gupta, S.K., Talwar, G.P. (1984). Paradoxical Effect of Antibodies Against Chorionic Gonadotropin on BeWo Choriocarcinoma Cells in Vitro and in Vivo: Evidence for Heterogeneity of Cell Types. In: Pattillo, R.A., Hussa, R.O. (eds) Human Trophoblast Neoplasms. Advances in Experimental Medicine and Biology, vol 176. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4811-5_15

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  • DOI: https://doi.org/10.1007/978-1-4684-4811-5_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4813-9

  • Online ISBN: 978-1-4684-4811-5

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