Abstract
The regulation of calcium release from bone is likely to be at least in part, dependant on cellular activity. In recent years it has been shown that the intracellular calcium concentration is important in regulating the activity of many cells from a wide range of tissues including those of the endocrine system and bone. There are several mechanisms involved in regulating cell calcium including calcium sodium (Ca-Na) exchange, calcium-magnesium sensitive ATPase and calcium transport via slow calcium channels1. Thus it is possible that by regulating intracellular calcium, some of these mechanisms could also regulate the cell mediated component of the transfer of calcium from bone to the extracellular fluid.
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References
R. P. Rubin “Calcium and cellular secretion”. Plenum Press New-York (1982)
P. J. Somerville and M. Kaye. “Studies on the action of inorganic phosphorus on calcium transport in isolated rat tails used as an organ perfusion system”. Kidney Internat. 22: 348–354 (1982)
O. Hauswirth and B. N. Singh, “Ionic mechanisms in heart muscle in relation to the genesic and pharmacological control of cardiac arrhytYunias. Pharmacol. Rev. 30: 5–63 (1979)
H. Fleish and R. Felix, “Diphosphonates”. Calcif. Tiss. Internat. 27: 91–96 (1979)
N. S. Kreiger and P. H. Tashjian, “Parathyroid hormone stimulates bone resorption via a Na-Ca exchange mechanism. Nature. 287: 843–845
P. Ducouret, “The effect of quinidine on membrane electrical activity in frog auricular fibres studied by current and voltage clamp. Brit. J. Pharmacol. 57: 163–184 (1976)
J. A. L. Arruda and S. Sabatini, “Effect of quinidine on Na, H and water transport by the turtle and toad bladders. J. Memb. Biol. 55: 151–147 (1980)
J. W. Dietrich, G. R. Mundy and L. G. Raisz. “Inhibition of bone resorption in tissue culture by membrane stabilizing drugs”. Endocrinology. 104: 1644–1648 (1979)
T. J. Hahn, C. R. Scharp, C. A. Richardson, L. R. Halstead, A. J. Kahn and S. J. Teitlebaum. “Interaction of diphenylhydantoin (phenytoin) and phenobarbital with hormonal mediation of fetal rat bone resorption in vitro”. J. Clin. Invest. 62: 406–414 (1978)
U. Lerner and L. Hanstrom. “Influence of diphenylhydantoin on on lysosomal enzyme release during bone resorption in vitro”. Acta Pharmacol. 47: 144–150 (1980)
L. C. Cantley, L. Josephson, R. Warner, M. Vanagisawa, C. Lechene, G. Guidotti. Vanadate is a potent (Na,K) ATPase inhibitor found in ATP derived from muscle“. J. Biol. Chem. 252: 7421–7423 (1977)
T. B. Simons. “Vanadate–a new tool for biologists”. Nature. 281: 337–338 (1979)
B. N. Singh, E. N. Vaughan-William. “A fourth class of anti-dysrhythmic action? Effect of verapamil on ouabain toxicity, on atrial and ventricular intracellular potentials and on other features of cardiac function”. Cardio-vasc. Research. 6: 109–119 (1972).
U. Lerner and G. T. Gustafson. “Inhibition of 1 hydroxy Vitamin-D3 stimulated bone resorption in tissue culture by the calcium antagonist verapamil”. Eur. J. of Clin. Investig. 12: 185–190 (1982)
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© 1984 Plenum Press, New York
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Somerville, P.J., Kaye, M. (1984). Effect of Calcium-Sodium Exchange and Calcium Channel Inhibition on Calcium Release from Bone in an in-vitro Bone Perfusion System. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_31
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DOI: https://doi.org/10.1007/978-1-4684-4808-5_31
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