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Inorganic Phosphate, Pyrophosphate and the Diphosphonates Activate Bone (Calvaria) Glutaminase

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Phosphate and Mineral Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 178))

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Abstract

Inorganic phosphate (Pi), pyrophosphate (PPi) and its synthetic analogues, dichloromethanediphosphonate (Cl2MDP) and 1-hydroxyethane-1, 1-diphosphonate (EHDP) compete for sites in bone mineral affecting the formation and dissolution of apatite.1 The diphosphonates may also affect the metabolism of bone and cartilage cells and possibly other tissues by interacting with enzymes or proteins which bind phosphate or phosphorylated intermediates. Available data indicate that Cl2MDP increases the production of CO2 from acetate, leucine, citrate and palmitate; stimulates the synthesis of collagen, proteoglycans and glycogen; increases alkaline phosphatase activity and inhibits lactate formation in cultured calvaria cells.2,3

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References

  1. H. Fleisch, R.G.G. Russell, and M. D. Francis, Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo, Science 165: 1262 (1969).

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  2. H. Fleisch and R. Felix, Diphosphonates, Calcif. Tiss. Intl. 27: 91 (1979).

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  3. R. Felix and H. Fleisch, Increase in fatty acid oxidation in calvaria cells cultured with diphosphonates, Biochem. J. 196: 237 (1981).

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  4. R. M. Biltz, J. M. Letteri, E. D. Pellegrino, A. Palekar, and L. M. Pinkus, Glutamine metabolism in bone, Mineral Electrolyte Metab. 9: 125 (1983).

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  5. E. Bernt and H. U. Bergmeyer, Glutamate; UV assay with glutamate dehydrogenase, and NAD, in: “Methods of Enzymatic Analysis,” H. U. Bergmeyer, ed., Academic Press, New York (1974).

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Author information

Authors and Affiliations

  1. Department of Medicine, Georgetown University Medical Center, Washington, D.C., USA

    R. M. Biltz, E. D. Pellegrino, J. M. Letteri & L. M. Pinkus

  2. Stony Brook and Nassau County Medical Center, SUNY, East Meadow, New York, USA

    R. M. Biltz, E. D. Pellegrino, J. M. Letteri & L. M. Pinkus

Authors
  1. R. M. Biltz
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  2. E. D. Pellegrino
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  3. J. M. Letteri
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  4. L. M. Pinkus
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. University of Verona, Verona, Italy

    Giuseppe Maschio

  3. University of Heidelberg, Heidelberg, Federal Republic of Germany

    Eberhard Ritz

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© 1984 Plenum Press, New York

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Biltz, R.M., Pellegrino, E.D., Letteri, J.M., Pinkus, L.M. (1984). Inorganic Phosphate, Pyrophosphate and the Diphosphonates Activate Bone (Calvaria) Glutaminase. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_30

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  • DOI: https://doi.org/10.1007/978-1-4684-4808-5_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4810-8

  • Online ISBN: 978-1-4684-4808-5

  • eBook Packages: Springer Book Archive

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