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Comparison of the Effect of Nucleotides on Phosphate Transport in Renal Brush Border Membrane Vesicles and Intact Proximal Tubules

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Phosphate and Mineral Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 178))

Abstract

It has been proposed that nicotinamide adenine dinucleotide (NAD) may be an important regulator of sodium-dependent phosphate (P) transport across the proximal tubular brush border membrane (BBM). NAD appears to cause inhibition of P uptake by BBM vesicles in vitro, and the in vivo administration of nicotinamide leads to phosphaturia1. The NAD effect on P-transport has been linked to ADP-ribosylation of the BBM2.

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References

  1. SA Kempson, G Colon-Otero, S-YL Ou, ST Turner, and T Dousa. Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat. J Clin Invest. 67: 1347–1360 (1981).

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  2. MR Hammerman, VA Hansen, and JJ Morrisey. ADP-ribosylation of canine renal brush border membrane vesicle protein is associated with decreased phosphate transport. J Biol Chem. 257: 1238012386 (1982).

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  3. RP Lang, N Yanagawa, EP Nord, L Sakhrani, S Lee, and LG Fine. Nucleotide inhibition of phosphate transport in the renal proximal tubule. Am J Physiol. In Press (1983).

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  4. HS Tenenhouse and YL Chu. Hydrolysis of nicotinamide-adenine dinucleotide by purified renal brush border membranes. Biochem J. 204: 635–638 (1982).

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  5. SG George and AJ Kenny. Studies on the enzymology of purified preparations of brush border from rabbit kidney. Biochem J. 134: 43–57 (1973).

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Author information

Authors and Affiliations

  1. Divisions of Nephrology, UCLA Center for the Health Sciences, Los Angeles, California, USA

    Leon G. Fine, Ronald Lang, Edward P. Nord & Norimoto Yanagawa

  2. Sepulveda Veterans Administration Hospital, University of California, Los Angeles School of Medicine, Los Angeles, California, USA

    Leon G. Fine, Ronald Lang, Edward P. Nord & Norimoto Yanagawa

Authors
  1. Leon G. Fine
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  2. Ronald Lang
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  3. Edward P. Nord
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  4. Norimoto Yanagawa
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. University of Verona, Verona, Italy

    Giuseppe Maschio

  3. University of Heidelberg, Heidelberg, Federal Republic of Germany

    Eberhard Ritz

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© 1984 Plenum Press, New York

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Fine, L.G., Lang, R., Nord, E.P., Yanagawa, N. (1984). Comparison of the Effect of Nucleotides on Phosphate Transport in Renal Brush Border Membrane Vesicles and Intact Proximal Tubules. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_10

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  • DOI: https://doi.org/10.1007/978-1-4684-4808-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4810-8

  • Online ISBN: 978-1-4684-4808-5

  • eBook Packages: Springer Book Archive

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